Date published: 2026-4-24

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6-Methoxynicotinamide (CAS 7150-23-4)

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CAS Number:
7150-23-4
Molecular Weight:
152.2
Molecular Formula:
C7H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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6-Methoxynicotinamide (6-MNA) is a noteworthy derivative of nicotinamide, a variant of vitamin B3, that has garnered substantial attention in biotechnological arenas. Notably, 6-Methoxynicotinamide exhibits anti-inflammatory, anti-diabetic, and anti-cancer properties in vitro. Its capacity to protect cells from oxidative stress and its involvement in gene expression regulation have also been subjects of investigation. Although the precise mechanism of action for 6-Methoxynicotinamide remains incompletely understood, it is believed to modulate the activity of enzymes associated with the synthesis and degradation of pro-inflammatory cytokines, as well as those involved in glucose metabolism. By exerting such modulation, 6-Methoxynicotinamide showcases its ability to regulate gene expression, safeguard cells against oxidative stress, and contribute to cellular homeostasis.


6-Methoxynicotinamide (CAS 7150-23-4) References

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  2. Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders.  |  Kannt, A., et al. 2021. Molecules. 26: PMID: 33668468
  3. Nicotinamide N-methyltransferase in endothelium protects against oxidant stress-induced endothelial injury.  |  Campagna, R., et al. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 119082. PMID: 34153425
  4. In silico insights into potential gut microbial modulation of NAD+ metabolism and longevity.  |  Salekeen, R., et al. 2021. J Biochem Mol Toxicol. 35: e22925. PMID: 34580953
  5. COVID-19: Are We Facing Secondary Pellagra Which Cannot Simply Be Cured by Vitamin B3?  |  Novak Kujundžić, R. 2022. Int J Mol Sci. 23: PMID: 35457123
  6. Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.  |  Ruf, S., et al. 2022. Sci Rep. 12: 15440. PMID: 36104373
  7. Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples.  |  Ueno, M., et al. 2020. Commun Chem. 3: 183. PMID: 36703437
  8. GPX8 regulates clear cell renal cell carcinoma tumorigenesis through promoting lipogenesis by NNMT.  |  Nguyen, TTM., et al. 2023. J Exp Clin Cancer Res. 42: 42. PMID: 36750850

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

6-Methoxynicotinamide, 1 g

sc-300024
1 g
$163.00

6-Methoxynicotinamide, 5 g

sc-300024A
5 g
$653.00