Vgl-3 アクチベーター

VGLL3 protein is a cofactor involved in transcription regulation, interacting with transcription factors from the TEAD family. The TEAD-VGLL3 complex binds to specific DNA sequences, modulating the expression of target genes. This process is important for various cellular processes, including cell proliferation and differentiation.Studies suggest that VGLL3 plays roles in immune system function and developmental processes. For instance, it's implicated in sex-biased autoimmune diseases, such as lupus, where its overexpression in females is thought to contribute to the higher incidence of disease.

In developmental biology, VGLL3 is thought to play a role in the formation of muscle tissue, given the homology to 'vestigial', a protein associated with wing development in fruit flies.VGLL3 is also implicated in cancer biology. Overexpression of VGLL3 has been found in certain types of cancer, including squamous cell carcinoma, where it is thought to contribute to tumorigenesis by promoting cell proliferation and inhibiting apoptosis.In short, VGLL3 is a multifunctional protein with roles in gene regulation, development, immune response, and potentially cancer.