SPRR2B activators belong to a class of chemical compounds designed to interact with and modulate the activity of the SPRR2B protein. SPRR2B, or Small Proline-Rich Protein 2B, is a member of the small proline-rich protein family, which is characterized by their high proline content and their involvement in various cellular processes such as differentiation, wound healing, and barrier function. SPRR2B, specifically, is primarily expressed in epithelial tissues, including the skin, oral mucosa, and esophagus, where it is believed to play crucial roles in maintaining tissue integrity and providing protection against environmental stressors. The designation activators suggests that these compounds engage with SPRR2B to modulate its activity, potentially leading to downstream effects on cellular physiology and tissue homeostasis.
Research into SPRR2B activators involves elucidating the molecular mechanisms underlying their interaction with the SPRR2B protein and how this interaction influences cellular processes, particularly in epithelial tissues. Understanding the pharmacological properties of these compounds is vital for deciphering how they impact SPRR2B activity and potentially affect epithelial barrier function, wound healing, and other physiological processes. By unraveling the biological functions and regulatory mechanisms of SPRR2B, researchers aim to deepen our understanding of epithelial biology and may uncover novel insights into the molecular pathways underlying tissue integrity and repair. Continued investigation into SPRR2B activators holds promise for advancing our knowledge of epithelial physiology and may provide insights into new strategies for manipulating tissue homeostasis in experimental contexts.
| 製品名 | CAS # | カタログ # | 数量 | 価格 | 引用文献 | レーティング |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ビタミンAの代謝産物であるオールトランス型レチノイン酸は皮膚細胞の分化に影響を及ぼし、レチノイドシグナル伝達に対する皮膚の反応の一部としてSPRR2Bをアップレギュレートする可能性がある。 | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
ビタミンDの活性型であるカルシトリオールは、皮膚細胞の成長と分化を調節し、表皮細胞におけるSPRR2Bの発現に影響を与える可能性がある。 | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
タザロテンは皮膚細胞の増殖と分化に影響を与え、おそらくSPRR2Bをアップレギュレートする。 | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
ニキビや乾癬の治療に使われるβヒドロキシ酸であるサリチル酸は、皮膚細胞の再生に対する効果を通じて、SPRR2Bの発現に影響を及ぼす可能性がある。 | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
ビタミンB3の一種であるニコチンアミドは抗炎症作用を持ち、皮膚のバリア修復と維持に関わるSPRR2Bの発現を調節する可能性がある。 | ||||||
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $208.00 | ||
ヒアルロン酸は、皮膚のバリア機能と修復を促進することにより、SPRR2Bの発現に影響を及ぼす可能性がある。 | ||||||
Glycerol | 56-81-5 | sc-29095A sc-29095 | 100 ml 1 L | $56.00 $153.00 | 12 | |
グリセロールは皮膚に水分を引き寄せ、皮膚の水分補給と修復の過程でSPRR2Bの発現に影響を与える可能性がある。 | ||||||