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Common GLI-2 Activators include, but are not limited to Purmorphamine CAS 483367-10-8, 20α-Hydroxy Cholesterol CAS 516-72-3, Smoothened Agonist, HCl CAS 364590-63-6, Vismodegib CAS 879085-55-9 and Cyclopamine CAS 4449-51-8.

GLI-2, or Glioma-associated oncogene homolog 2, activators are compounds or molecules that modulate the activity of the GLI-2 protein. GLI-2 is a transcription factor and a key component of the Hedgehog signaling pathway, which is vital for various developmental processes and tissue homeostasis. This pathway plays a crucial role in embryonic development, stem cell maintenance, and tissue repair in adults. The activation of GLI-2 involves a complex regulatory mechanism, and GLI-2 activators are substances that can influence this activation process. Understanding the role of GLI-2 and its regulation is essential in developmental biology, regenerative medicine, and cancer research, as dysregulation of the Hedgehog pathway, including GLI-2, has been associated with various cancers.

GLI-2 activators can serve as important tools for researchers investigating the precise mechanisms of Hedgehog signaling and its downstream effects on gene expression. By manipulating GLI-2 activity, scientists can gain insights into how this pathway influences cellular processes, such as proliferation, differentiation, and tissue regeneration. These activators allow researchers to study the role of GLI-2 in both normal and pathological conditions, contributing to a deeper understanding of its significance in various biological contexts.