fushi tarazu アクチベーター

The fushi tarazu (ftz) gene is a well-studied member of the Hox gene family, found in the fruit fly Drosophila melanogaster. The protein encoded by the ftz gene is a transcription factor, which means it helps regulate the activity of other genes.The term "fushi tarazu" is Japanese for "incomplete or not fully developed segments," reflecting the gene's role in segment formation during Drosophila embryogenesis. Mutations in this gene result in a "fushi tarazu" phenotype, where alternate segments of the fly's body are missing, leading to a shorter, improperly segmented larva.

Interestingly, the ftz gene is not part of the main Hox cluster that determines the identity of body segments along the anterior-posterior axis of the fly. Instead, it has evolved a role in regulating the cell cycle and neuronal development. This dual role in segmentation and neuronal development is unique within the Hox gene family and makes the ftz gene a fascinating subject of developmental biology research.The ftz protein functions as a homeodomain protein, a type of protein that binds to specific DNA sequences to control the transcription of genetic information from DNA to mRNA. Homeodomain proteins are critical for the proper development of an organism, helping to ensure that cells differentiate and mature into the correct cell types at the right times.