ZLJ-6 is an inhibitor of Cox-1 (cyclooxygenase-1) (IC50 = 0.73 μM), Cox-2 (IC50 = 0.31 μM), and 5-LO (5-lipoxygenase) (IC50 = 0.99 μM). ZLJ-6 reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective Cox inhibitors.
1 Li, L., Ji, H., Sheng, L., et al. The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. Eur J Pharmacol 607 (1-3) 244-250 (2009).