Molecular structure of VUF 8430 dihydrobromide, CAS Number: 100130-32-3
VUF 8430 dihydrobromide (CAS 100130-32-3)
Application:
VUF 8430 dihydrobromide is a potent histamine H4 receptor full agonist
CAS Number:
100130-32-3
Molecular Weight:
323.05
Molecular Formula:
C4H11N5S•2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
VUF 8430 dihydrobromide is a novel synthetic compound. Derived from the naturally occurring compound dihydrobromide found in certain plants and fungi, VUF 8430 dihydrobromide exhibits a wide range of biological activities. In vitro investigations have revealed its ability to inhibit the growth of numerous cancer cell lines and induce apoptosis in specific cell lines. Although the precise mechanism of action of VUF 8430 dihydrobromide remains incompletely understood, it is believed to involve the inhibition of protein kinases, enzymes that regulate cell growth and differentiation.
VUF 8430 dihydrobromide (CAS 100130-32-3) References
- Voltage sensitivities and deactivation kinetics of histamine H₃ and H₄ receptors. | Sahlholm, K., et al. 2012. Biochim Biophys Acta. 1818: 3081-9. PMID: 22885137
- Osthole inhibits histamine-dependent itch via modulating TRPV1 activity. | Yang, NN., et al. 2016. Sci Rep. 6: 25657. PMID: 27160770
- Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation. | Frick, L., et al. 2016. Brain Behav Immun. 57: 326-337. PMID: 27381299
- Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. | Tabakawa, Y., et al. 2018. Front Immunol. 9: 1540. PMID: 30034394
- Compound 48/80 reduces the crop-emptying rate, likely through a histamine-associated pathway in chicks. | Tachibana, T., et al. 2019. Domest Anim Endocrinol. 66: 57-63. PMID: 30472035
- MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux. | Rodríguez González, A., et al. 2021. FEBS J. 288: 229-243. PMID: 32333821
- The Histamine H4 Receptor Participates in the Neuropathic Pain-Relieving Activity of the Histamine H3 Receptor Antagonist GSK189254. | Borgonetti, V. and Galeotti, N. 2022. Int J Mol Sci. 23: PMID: 36430790
Inhibitor of:
Histamine H4 Receptor.Activator of:
Histamine H4 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VUF 8430 dihydrobromide, 5 mg | sc-203719 | 5 mg | $70.00 | |||
VUF 8430 dihydrobromide, 50 mg | sc-203719A | 50 mg | $570.00 |