Venturicidin B CAS: 33538-72-6
MF: C40H66O10
MW: 706.9

Venturicidin B (CAS 33538-72-6)

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Nomi alternativi: Aabomycin A2
Applicazione: Venturicidin B is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector
Numero CAS: 33538-72-6
Purezza: >95%
Peso molecolare: 706.9
Formula molecolare: C40H66O10
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
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Venturicidin B is an antibiotic that has been reported to be a potent inhibitor of the ATP5 (mitochondrial ATP synthase complex). This compound interferes with the F0 portion of membrane-located K+ and H+-ATPase channels and decreases probability of the channels from opening. By blocking proton transfer across the membrane, Venuricidin B causes a halt in ATP synthase activity.


Referenze

1. Galanis, M., et al. 1989. FEBS Lett. 249: 333-336. PMID: 2661266

2. Matsuno-Yagi, A. and Hatefi, Y. 1993. J. Biol. Chem. 268: 6168-6173. PMID: 8454592

3. Miedema, H., et al. 1994. Biochem. Biophys. Res. Commun. 203: 1005-1012. PMID: 8093018

Aspetto :
Lyophilized
Stato fisico :
Solid
Derivato da :
Streptomyces sp.
Solubilità :
Soluble in ethanol, methanol, DMF, DMSO, and water (poor).
CONSERVAZIONE :
Store at 4° C
Punto di scioglimento :
145-149° C
Punto di ebollizione :
~823.4° C at 760 mmHg (Predicted)
Densità :
~1.1 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.54 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
Numero MDL :
MFCD08061904
SMILES :
CCC(=O)C(C)C(C(C)CC(C)C1C(CC(C=CC(CCCC=C(C2C(=CCC(O2)(CC(=O)O1)O)C)C)OC3CC(C(C(O3)C)O)O)C)C)O

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