TSSK 2 Antibody (S-09): sc-100437

TSSK 2 Antibody (S-09) is a mouse monoclonal IgG1 antibody that detects TSSK 2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-TSSK 2 antibody (S-09) is available as a non-conjugated format. TSSK 2, also known as testis-specific serine kinase 2, DGS-G (DiGeorge syndrome protein G), SPOGA2, or STK22B (serine/threonine-protein kinase 22B), is a serine/threonine kinase that plays a crucial role in the late stages of spermatogenesis, localizing primarily to the cytoplasm. TSSK 2 is characterized by a single protein kinase domain and utilizes magnesium as a cofactor to catalyze the transfer of a phosphate group from ATP to target proteins, such as SPAG16. TSSK 2 (S-09) monoclonal antibody enables research into male fertility and developmental disorders, as loss of TSSK 2 due to chromosomal deletion has been implicated in velocardiofacial/DiGeorge syndrome (VCFS/DGS), which is characterized by a range of developmental anomalies including palate and facial deformities, immunodeficiency, and cardiac malformations. With significant roles in both reproductive biology and developmental health, anti-TSSK 2 antibody (S-09) serves as a valuable tool for researchers studying these critical areas.

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TSSK 2 Antibody (S-09) References:

1. A novel member of the testis specific serine kinase family, tssk-3, expressed in the Leydig cells of sexually mature mice.  |  Zuercher, G., et al. 2000. Mech Dev. 93: 175-7. PMID: 10781952
2. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.  |  Hao, Z., et al. 2004. Mol Hum Reprod. 10: 433-44. PMID: 15044604
3. Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.  |  Xu, B., et al. 2007. Soc Reprod Fertil Suppl. 63: 87-101. PMID: 17566264
4. Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2.  |  Zhang, Z., et al. 2008. Biol Reprod. 79: 75-83. PMID: 18367677
5. DAZL binds to the transcripts of several Tssk genes in germ cells.  |  Zeng, M., et al. 2008. BMB Rep. 41: 300-4. PMID: 18452650
6. A novel family of serine/threonine kinases participating in spermiogenesis.  |  Kueng, P., et al. 1997. J Cell Biol. 139: 1851-9. PMID: 9412477

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TSSK 2 Antibody (S-09) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TSSK 2 Antibody (S-09) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TSSK 2 Antibody (S-09) Specifications

Alternate Product Name: TSSK 2

Product Clone Name: S-09

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 265-358

Epitope Target: TSSK 2

Epitope Species: human

Product Reactivity/Detection: TSSK 2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TSSK 2 Antibody (S-09): N/A