TSPY Antibody (H-11): sc-137050

TSPY Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects TSPY protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TSPY (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The testis-specific protein Y-encoded (TSPY) is encoded by a gene cluster located on the human proximal Yp chromosome and has been conserved across mammalian species for over 80 million years, highlighting evolutionary significance. TSPY plays a crucial role in cell cycle regulation, cell proliferation, and tumorigenesis, making TSPY a key player in the development of various cancers, including gonadoblastoma, testicular germ cell tumors, prostate cancer, melanoma, and liver cancer. Notably, TSPY expression is regulated by the Sox family of proteins, and TSPY activity is dependent on phosphorylation, which is essential for function in oncogenesis. Furthermore, TSPY has emerged as a promising candidate for immunotherapy strategies, particularly in hepatocellular carcinoma, where TSPY may contribute to the development of effective vaccine approaches.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

TSPY Antibody (H-11) References:

1. Characterization of a new TSPY gene family member in Yq (TSPYq1).  |  Ratti, A., et al. 2000. Cytogenet Cell Genet. 88: 159-62. PMID: 10773691
2. TSPY variants in six loci on the human Y chromosome.  |  Dechend, F., et al. 2000. Cytogenet Cell Genet. 91: 67-71. PMID: 11173833
3. Generation and characterization of a transgenic mouse with a functional human TSPY.  |  Schubert, S., et al. 2003. Biol Reprod. 69: 968-75. PMID: 12773407
4. TSPY detection in blood, buccal, and urine cells of patients with 45,X karyotype.  |  Bartmann, AK., et al. 2004. Am J Med Genet A. 130A: 320-1. PMID: 15378555
5. TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma.  |  Yin, YH., et al. 2005. Br J Cancer. 93: 458-63. PMID: 16106251
6. Characterization of a human TSPY promoter.  |  Skawran, B., et al. 2005. Mol Cell Biochem. 276: 159-67. PMID: 16132697
7. Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma.  |  Su, MT., et al. 2006. Gynecol Oncol. 103: 357-60. PMID: 16784771
8. Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues.  |  Schnieders, F., et al. 1996. Hum Mol Genet. 5: 1801-7. PMID: 8923009

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TSPY Antibody (H-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TSPY Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TSPY Antibody (H-11) Specifications

Alternate Product Name: TSPY

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-120

Epitope Target: TSPY

Epitope Species: human

Product Reactivity/Detection: TSPY

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TSPY Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin