Thyroglobulin Antibody (PB3): sc-73514

Thyroglobulin Antibody (PB3) is a mouse monoclonal IgG1 antibody that detects thyroglobulin in human samples through enzyme-linked immunosorbent assay (ELISA). Anti-thyroglobulin antibody (PB3) recognizes a large preprotein that plays a crucial role in the synthesis of the iodinated thyroid hormones thyroxine and triiodothyronine, which are essential for regulating metabolism, growth, and development in the body. Thyroglobulin monoclonal antibody (PB3) targets a protein primarily located in the thyroid gland, where thyroglobulin serves as a precursor that undergoes complex post-translational modifications, including glycosylation, which are vital for stability and function. These modifications not only facilitate proper folding and maturation of thyroglobulin but also influence interactions with other proteins during hormone synthesis. Defects in thyroglobulin can lead to various thyroid disorders, including goiter, which is characterized by thyroid gland enlargement due to impaired dimerization and transport of thyroglobulin to the Golgi complex. Thyroglobulin (PB3) antibody serves as an invaluable tool for researchers studying thyroid function and related pathologies, providing insights into molecular mechanisms underlying thyroid hormone production and regulation.

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Thyroglobulin Antibody (PB3) References:

1. Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery.  |  Haddow, JE., et al. 2010. Obstet Gynecol. 116: 58-62. PMID: 20567168
2. Thyroperoxidase and thyroglobulin antibodies in early pregnancy and placental abruption.  |  Haddow, JE., et al. 2011. Obstet Gynecol. 117: 287-292. PMID: 21252741
3. Iodine contributes to thyroid autoimmunity in humans by unmasking a cryptic epitope on thyroglobulin.  |  Latrofa, F., et al. 2013. J Clin Endocrinol Metab. 98: E1768-74. PMID: 24064687
4. Thyroglobulin production by malignant thyroid tumors. An immunocytochemical and radioimmunoassay study.  |  Ryff-de Lèche, A., et al. 1986. Cancer. 57: 1145-53. PMID: 2417694
5. Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic 131I in the differentiated thyroid cancers.  |  Trevizam, PG., et al. 2017. Endocr Res. 42: 42-48. PMID: 27144920
6. Consensus sequences for early iodination and hormonogenesis in human thyroglobulin.  |  Lamas, L., et al. 1989. J Biol Chem. 264: 13541-5. PMID: 2760035
7. Studies of immune-complex glomerulonephritis mediated by human thyroglobulin.  |  Jordan, SC., et al. 1981. N Engl J Med. 304: 1212-5. PMID: 7012624
8. Thyroid peroxidase in dyshormonogenetic goiters with organification and thyroglobulin defects.  |  de Carvalho, DP., et al. 1994. Thyroid. 4: 421-6. PMID: 7711505
9. Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma.  |  Spencer, CA., et al. 1998. J Clin Endocrinol Metab. 83: 1121-7. PMID: 9543128
10. Immunoradiometric assay of thyroglobulin in patients with differentiated thyroid carcinomas: need for thyroglobulin recovery tests.  |  Bourrel, F., et al. 1998. Clin Chem Lab Med. 36: 725-30. PMID: 9804398

The preferred Thyroglobulin antibody is Thyroglobulin Antibody (D-9): sc-365997.