Sos 2 Antibody (G-7): sc-25350
- Sos 2 Antibody (G-7) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1091-1170 of Sos 2 of human origin
- recommended for detection of Sos 2 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sos 2 Antibody (G-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Sos 2 Antibody (G-7) (see ordering information below).
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Sos 2 Antibody (G-7) is a mouse monoclonal IgG2b antibody that detects Sos 2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sos 2, a member of the guanine nucleotide exchange factor family, plays a crucial role in the activation of Ras proteins, which are pivotal in regulating cell growth, differentiation, and survival. Sos 2 facilitates the exchange of GDP for GTP on Ras, thereby promoting the active form of Ras that interacts with downstream effectors such as Raf, leading to the activation of the MAP kinase signaling pathway. This pathway is essential for transmitting signals from cell surface receptors to the nucleus, influencing gene expression and cellular responses. Sos 2 (G-7) antibody enables researchers to examine signaling networks involved in cancer and other diseases, providing detailed insights into Sos 2′s role in Ras activation and subsequent effects on cellular functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sos 2 Antibody (G-7) References:
- Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome. | Yamamoto, GL., et al. 2015. J Med Genet. 52: 413-21. PMID: 25795793
- Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome. | Cordeddu, V., et al. 2015. Hum Mutat. 36: 1080-7. PMID: 26173643
- Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation. | Sheffels, E., et al. 2018. Sci Signal. 11: PMID: 30181243
- Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells. | Sheffels, E., et al. 2021. Small GTPases. 12: 67-78. PMID: 31062644
- Variants of SOS2 are a rare cause of Noonan syndrome with particular predisposition for lymphatic complications. | Lissewski, C., et al. 2021. Eur J Hum Genet. 29: 51-60. PMID: 32788663
- SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology. | Baltanás, FC., et al. 2021. Int J Mol Sci. 22: PMID: 34205562
- Genetic variants of SOS2, MAP2K1 and RASGRF2 in the RAS pathway genes predict survival of HBV-related hepatocellular carcinoma patients. | Lin, Q., et al. 2023. Arch Toxicol. 97: 1599-1611. PMID: 37029817
- SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma. | Theard, PL., et al. 2024. Mol Oncol. 18: 641-661. PMID: 38073064
- Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2). | Zak, KM., et al. 2025. J Med Chem. 68: 2680-2693. PMID: 39818983
- Differential interactions of human Sos1 and Sos2 with Grb2. | Yang, SS., et al. 1995. J Biol Chem. 270: 18212-5. PMID: 7629138
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sos 2 Antibody (G-7) | sc-25350 | 200 µg/ml | $322.00 | |||
Sos 2 Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-536707 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sos 2 Antibody (G-7): m-IgGκ BP-HRP Bundle | sc-533867 | 200 µg Ab; 40 µg BP | $361.00 | |||
Sos 2 Antibody (G-7): m-IgG2b BP-HRP Bundle | sc-549821 | 200 µg Ab; 10 µg BP | $361.00 |