SHIP-2 Antibody (Z-16): sc-100387
- SHIP-2 Antibody (Z-16) is a mouse monoclonal mouse IgG1 κ κ provided at 100 µg/ml
- raised against recombinant SHIP-2 of human origin
- recommended for detection of SHIP-2 of mouse, rat and human origin by WB, IP and ELISA
- See SHIP-2 (E-2): sc-166641 for SHIP-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SHIP-2 Antibody (Z-16). This work is in progress.
SHIP-2 Antibody (Z-16) is a mouse monoclonal IgG1 antibody that detects SHIP-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). SHIP-2, a homolog of SHIP, plays a crucial role in cellular signaling pathways, particularly in the regulation of the phosphoinositide 3-kinase (PI3K) pathway, which is vital for cell growth and survival. SHIP-2 is primarily located in the cytoplasm and interacts with various signaling molecules, including Shc, following receptor activation. This interaction leads to the modulation of downstream signaling cascades that influence cell cycle progression and apoptosis. SHIP-2 mediates the effects of the B-cell receptor and FcgRII, contributing to the negative regulation of cell proliferation, particularly in immune cells. SHIP-2 expression extends beyond hematopoietic cells to non-hematopoietic tissues, including the heart and brain, highlighting diverse functional roles across different cell types. SHIP-2′s ability to induce cell cycle arrest in the G1 phase in glioblastoma cells underscores its importance in cancer biology, making SHIP-2 a valuable target for research in both immunology and oncology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SHIP-2 Antibody (Z-16) References:
- SHIP2: an emerging target for the treatment of type 2 diabetes mellitus. | Baumgartener, JW. 2003. Curr Drug Targets Immune Endocr Metabol Disord. 3: 291-8. PMID: 14683460
- The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2. | Dyson, JM., et al. 2005. Int J Biochem Cell Biol. 37: 2260-5. PMID: 15964236
- SHIP2 and its involvement in various diseases. | Suwa, A., et al. 2010. Expert Opin Ther Targets. 14: 727-37. PMID: 20536411
- SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties. | Erneux, C., et al. 2011. J Cell Biochem. 112: 2203-9. PMID: 21503961
- SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts. | Elong Edimo, W., et al. 2013. Adv Biol Regul. 53: 28-37. PMID: 23040614
- Suppression of SHIP2 contributes to tumorigenesis and proliferation of gastric cancer cells via activation of Akt. | Ye, Y., et al. 2016. J Gastroenterol. 51: 230-40. PMID: 26201869
- SHIP2: Structure, Function and Inhibition. | Thomas, MP., et al. 2017. Chembiochem. 18: 233-247. PMID: 27907247
- SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors. | Lehtonen, S. 2020. Acta Physiol (Oxf). 228: e13349. PMID: 31342643
- Small molecule targeting of SHIP1 and SHIP2. | Kerr, WG., et al. 2020. Biochem Soc Trans. 48: 291-300. PMID: 32049315
- PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer. | Xu, L., et al. 2024. J Exp Clin Cancer Res. 43: 17. PMID: 38200519
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SHIP-2 Antibody (Z-16) | sc-100387 | 100 µg/ml | $339.00 |