Sarcalumenin Antibody (XIIC4): sc-58845
- Sarcalumenin Antibody (XIIC4) is a mouse monoclonal IgG1 κ Sarcalumenin antibody, cited in 4 publications, provided at 200 µg/ml
- raised against purified Sarcalumenin of rat origin
- Sarcalumenin Antibody (XIIC4) is recommended for detection of Sarcalumenin and the 53 kDa glycoprotein splice variant of mouse, rat, human, rabbit and canine origin by WB and IP
- Anti-Sarcalumenin Antibody (XIIC4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Sarcalumenin Antibody (XIIC4) for WB applications. These reagents are now offered in bundles with Sarcalumenin Antibody (XIIC4) (see ordering information below).
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Sarcalumenin Antibody (XIIC4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sarcalumenin protein of mouse, rat, human, rabbit, and canine origin by western blotting (WB) and immunoprecipitation (IP). Anti-Sarcalumenin antibody (XIIC4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sarcalumenin plays a crucial role in muscle physiology by facilitating calcium handling within the sarcoplasmic reticulum, which is essential for muscle contraction and relaxation. Sarcalumenin is located in the longitudinal tubules of the sarcoplasmic reticulum in striated muscle cells, where Sarcalumenin binds calcium ions and helps sequester them in nonjunctional regions. This localization ensures efficient calcium storage and release, allowing for rapid muscle responses during contraction and relaxation cycles. Sarcalumenin interacts with calcium pump proteins, enhancing their function and contributing to overall calcium homeostasis in muscle cells. While basic muscle functions can occur without Sarcalumenin, absence of Sarcalumenin leads to impaired contraction and relaxation dynamics, highlighting Sarcalumenin′s importance in maintaining muscle performance and health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sarcalumenin Antibody (XIIC4) References:
- Cardiac sarcalumenin: phosphorylation, comparison with the skeletal muscle sarcalumenin and modulation of ryanodine receptor. | Hadad, N., et al. 1999. J Membr Biol. 170: 39-49. PMID: 10398759
- Expression and characterisation of a Plasmodium falciparum protein containing domains homologous to sarcalumenin and a tyrosine kinase substrate, eps15. | McDaniel, JP., et al. 1999. Int J Parasitol. 29: 723-30. PMID: 10404267
- Drastic reduction of sarcalumenin in Dp427 (dystrophin of 427 kDa)-deficient fibres indicates that abnormal calcium handling plays a key role in muscular dystrophy. | Dowling, P., et al. 2004. Biochem J. 379: 479-88. PMID: 14678011
- Drastic reduction in the luminal Ca2+ -binding proteins calsequestrin and sarcalumenin in dystrophin-deficient cardiac muscle. | Lohan, J. and Ohlendieck, K. 2004. Biochim Biophys Acta. 1689: 252-8. PMID: 15276652
- Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice. | Yoshida, M., et al. 2005. J Biol Chem. 280: 3500-6. PMID: 15569689
- Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. | Zhao, X., et al. 2005. Physiol Genomics. 23: 72-8. PMID: 15998745
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sarcalumenin Antibody (XIIC4) | sc-58845 | 200 µg/ml | $322.00 | |||
Sarcalumenin Antibody (XIIC4): m-IgG Fc BP-HRP Bundle | sc-528630 | 200 µg Ab; 10 µg BP | $361.00 | |||
Sarcalumenin Antibody (XIIC4): m-IgGκ BP-HRP Bundle | sc-521060 | 200 µg Ab, 40 µg BP | $361.00 | |||
Sarcalumenin Antibody (XIIC4): m-IgG1 BP-HRP Bundle | sc-543040 | 200 µg Ab; 20 µg BP | $361.00 | |||
Sarcalumenin Antibody (XIIC4) AC | sc-58845 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Sarcalumenin Antibody (XIIC4) HRP | sc-58845 HRP | 200 µg/ml | $322.00 | |||
Sarcalumenin Antibody (XIIC4) FITC | sc-58845 FITC | 200 µg/ml | $336.00 | |||
Sarcalumenin Antibody (XIIC4) PE | sc-58845 PE | 200 µg/ml | $349.00 | |||
Sarcalumenin Antibody (XIIC4) Alexa Fluor® 488 | sc-58845 AF488 | 200 µg/ml | $364.00 | |||
Sarcalumenin Antibody (XIIC4) Alexa Fluor® 546 | sc-58845 AF546 | 200 µg/ml | $364.00 | |||
Sarcalumenin Antibody (XIIC4) Alexa Fluor® 594 | sc-58845 AF594 | 200 µg/ml | $364.00 | |||
Sarcalumenin Antibody (XIIC4) Alexa Fluor® 647 | sc-58845 AF647 | 200 µg/ml | $364.00 | |||
Sarcalumenin Antibody (XIIC4) Alexa Fluor® 680 | sc-58845 AF680 | 200 µg/ml | $364.00 | |||
Sarcalumenin Antibody (XIIC4) Alexa Fluor® 790 | sc-58845 AF790 | 200 µg/ml | $364.00 |