S-100A2 Antibody (SH-L1): sc-58844
- S-100A2 Antibody (SH-L1) is a mouse monoclonal IgG1 S-100A2 antibody, cited in 1 publications, provided at 100 µl ascites
- raised against full length native S-100A2 of porcine origin
- recommended for detection of S-100A2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and bovine, porcine, feline and canine; non cross-reactive with other members of the EF-hand family including calmodulin, parvalbumin, intestinal calcium-binding protein, S-100A6 (calcyclin), caltropin, S-100 α chain or S-100 β chain
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for S-100A2 Antibody (SH-L1). This work is in progress.
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S-100A2 Antibody (SH-L1) is a mouse monoclonal IgG1 antibody that detects S-100A2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-S-100A2 antibody (SH-L1) is available as the non-conjugated format. S-100A2 protein, also known as S100 calcium binding protein A2, belongs to the S-100 protein family, characterized by calcium binding ability and involvement in various intracellular processes. S-100A2 protein is primarily found in the basal layer of the epidermis and hair follicles, playing a crucial role in skin homeostasis and cellular signaling. S-100A2 protein regulates cell motility, particularly in cancer, as expression is often lost during malignant transformation of epithelial cells, such as in breast cancer. Loss of S-100A2 expression may contribute to increased cell migration and metastasis, suggesting a tumor-suppressive role in certain tissues. Neoplastic gastric epithelial cells express S-100A2 alongside other S-100 family members, indicating relevance in cancer biology. S-100A2 protein interacts with Tropomyosin in a calcium-dependent manner, highlighting importance in cellular dynamics and potential therapeutic targeting in cancer treatment.
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S-100A2 Antibody (SH-L1) References:
- Expression of calcium-binding protein S100A2 in breast lesions. | Liu, D., et al. 2000. Br J Cancer. 83: 1473-9. PMID: 11076656
- S100A2, a putative tumor suppressor gene, regulates in vitro squamous cell carcinoma migration. | Nagy, N., et al. 2001. Lab Invest. 81: 599-612. PMID: 11304580
- Gastric cancers overexpress S100A calcium-binding proteins. | El-Rifai, W., et al. 2002. Cancer Res. 62: 6823-6. PMID: 12460893
- Isolation of a new member of the S100 protein family: amino acid sequence, tissue, and subcellular distribution. | Glenney, JR., et al. 1989. J Cell Biol. 108: 569-78. PMID: 2521861
- Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins. | Gimona, M., et al. 1997. J Cell Sci. 110 (Pt 5): 611-21. PMID: 9092943
- Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. | Böni, R., et al. 1997. Br J Dermatol. 137: 39-43. PMID: 9274623
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-100A2 Antibody (SH-L1) | sc-58844 | 100 µl ascites | $322.00 |