Rock-1 Antibody (B-1): sc-374388
- Rock-1 Antibody (B-1) is a mouse monoclonal IgG2a κ, cited in 9 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1309-1346 near the C-terminus of Rock-1 of human origin
- recommended for detection of Rock-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and bovine
- See Rock-1 (G-6): sc-17794 for Rock-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Rock-1 Antibody (B-1) for WB applications. These reagents are now offered in bundles with Rock-1 Antibody (B-1) (see ordering information below).
Rock-1 Antibody (B-1) is a mouse monoclonal IgG2a kappa light chain antibody engineered to detect Rho-associated, coiled-coil containing protein kinase 1 (ROCK1), also known as ROKα, across multiple species including mouse, rat, human, equine, canine, and bovine. ROCK1 monoclonal antibody (B-1) targets an epitope within amino acids 1309-1346 near the C-terminus of the human ROCK1 protein, ensuring reliable detection in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ROCK1 is a critical serine/threonine kinase involved in regulating the actin cytoskeleton, influencing the formation of stress fibers, focal adhesions, and the contractile ring, which are essential for processes like cytokinesis and cell migration. ROCK1 interacts with several key proteins, including myosin light chain (MLC) to regulate contractility, LIM kinase to influence actin filament dynamics, and the small GTPase RhoA, which activates ROCK1 and modulates various downstream signaling pathways. These interactions make ROCK1 pivotal in maintaining cell shape, enabling signal transduction pathways that affect cell proliferation, apoptosis, and migration, and playing significant roles in physiological and pathological processes such as cancer metastasis, cardiovascular diseases, and neurological disorders. ROCK1 monoclonal antibody (B-1) facilitates the detailed study of these interactions by providing consistent and precise detection of ROCK1 in diverse experimental settings. The broad species reactivity of ROCK1 antibody (B-1) enhances versatility for comparative studies and translational research, allowing researchers to explore the conserved mechanisms of ROCK1 function across different organisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rock-1 Antibody (B-1) | sc-374388 | 200 µg/ml | $322.00 | |||
Rock-1 Antibody (B-1): m-IgG Fc BP-HRP Bundle | sc-540447 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rock-1 Antibody (B-1): m-IgG2a BP-HRP Bundle | sc-546907 | 200 µg Ab; 10 µg BP | $361.00 | |||
Rock-1 (B-1) Neutralizing Peptide | sc-374388 P | 100 µg/0.5 ml | $69.00 |