Reveromycin A CAS: 134615-37-5
MF: C36H52O11
MW: 660.8
A spiroketal antibiotic inhibitor of EGF mitogenic activity.

Reveromycin A (CAS 134615-37-5)

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Applicazione: Reveromycin A is a spiroketal antibiotic inhibitor of EGF mitogenic activity
Numero CAS: 134615-37-5
Purezza: >99%
Peso molecolare: 660.8
Formula molecolare: C36H52O11
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF (epidermal growth factor). It is a G1 phase cell cycle inhibitor, selectively inhibiting IleRS (isoleucyl-tRNA synthetase). Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.


Referenze

1. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Woo J.T. et al. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 4729. 2. Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity. Muguruma H. et al. Clin. Cancer Res. 2005, 11, 8822. 3. Identification of Saccharomyces cerevisiae isoleucyl-tRNA synthetase as a target of the G1-specific inhibitor Reveromycin A. Miyamoto Y. et al. J. Biol. Chem. 2002, 277, 28810. 4. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. Takahashi H. et al. J. Antibiot. 1992, 45, 1414.

Aspetto :
Lyophilized
Stato fisico :
Solid
Derivato da :
Streptomyces sp.
Solubilità :
Soluble in ethyl acetate, ethanol, methanol, DMF, and DMSO.
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
849.02° C at 760 mmHg (Predicted)
Densità :
1.22 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.56 (Predicted)
IC50 :
IleRS: IC50 = 1.97 nM (rat); IleRS: IC50 = 4.46 nM (human); NRK: EC5050 = 2.39 µM (rat)
Valori pK :
pKa: 4.36 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
PubChem CID :
Numero MDL :
MFCD00912537
SMILES :
CCCCC1(CCC2(CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)OC1C=CC(=CC(=O)O)C)OC(=O)CCC(=O)O

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CERTIFICATO DI ANALISI

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Reveromycin A (CAS 134615-37-5)  Citazioni prodotti

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PMID: # 18840695  Yano, A. et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105: 15541-15546.

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