Relaxin Receptor 2 Antibody (H-4): sc-374293

Relaxin Receptor 2 Antibody (H-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Relaxin Receptor 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Relaxin Receptor 2 (H-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Relaxin Receptor 2, also known as Relaxin/insulin-like family peptide receptor 2, RXFP2, LGR8, GREAT, GPR106, INSL3R, or RXFPR2, is a crucial member of the G protein-coupled receptor family, which plays a significant role in mediating extracellular signals into intracellular responses. Relaxin Receptor 2 is primarily located in the cell membrane and is characterized by ten leucine-rich repeats and an LDL-receptor class A domain. Upon binding with ligands, Relaxin or insulin-like peptide 3 (INSL3), Relaxin Receptor 2 activates adenylate cyclase, resulting in an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. cAMP is a vital second messenger that regulates various physiological processes, including hormone signaling and cellular activity modulation. Proper functioning of Relaxin Receptor 2 is essential, as mutations in the gene encoding this receptor can lead to conditions such as cryptorchidism, which is associated with an increased risk of infertility and testicular cancer. Using anti-Relaxin Receptor 2 antibody (H-4) in research can provide valuable insights into the signaling pathways and physiological roles of this important receptor.

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Relaxin Receptor 2 Antibody (H-4) References:

1. A transgenic insertion causing cryptorchidism in mice.  |  Overbeek, PA., et al. 2001. Genesis. 30: 26-35. PMID: 11353515
2. Activation of orphan receptors by the hormone relaxin.  |  Hsu, SY., et al. 2002. Science. 295: 671-4. PMID: 11809971
3. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.  |  Kumagai, J., et al. 2002. J Biol Chem. 277: 31283-6. PMID: 12114498
4. Mutations of the GREAT gene cause cryptorchidism.  |  Gorlov, IP., et al. 2002. Hum Mol Genet. 11: 2309-18. PMID: 12217959
5. The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism.  |  Ferlin, A., et al. 2003. J Clin Endocrinol Metab. 88: 4273-9. PMID: 12970298
6. Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.  |  Muda, M., et al. 2005. Mol Hum Reprod. 11: 591-600. PMID: 16051677
7. Peters Plus syndrome is caused by mutations in B3GALTL, a putative glycosyltransferase.  |  Lesnik Oberstein, SA., et al. 2006. Am J Hum Genet. 79: 562-6. PMID: 16909395
8. Relaxin-like ligand-receptor systems are autocrine/paracrine effectors in tumor cells and modulate cancer progression and tissue invasiveness.  |  Klonisch, T., et al. 2007. Adv Exp Med Biol. 612: 104-18. PMID: 18161484

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Relaxin Receptor 2 Antibody (H-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Relaxin Receptor 2 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Relaxin Receptor 2 Antibody (H-4) Specifications

Alternate Product Name: Relaxin Receptor 2

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 81-230

Epitope Target: Relaxin Receptor 2

Epitope Species: human

Product Reactivity/Detection: Relaxin Receptor 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Relaxin Receptor 2 Antibody (H-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin