PTP1B Inhibitor Inibitore CAS: 765317-72-4
MF: C26H19Br2N3O7S3
MW: 741.5

PTP1B Inhibitor Inibitore (CAS 765317-72-4)

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Nomi alternativi: PTP1B Inhibitor is also known as Protein Tyrosine Phosphatase 1B Inhibitor.
Applicazione: PTP1B Inhibitor is a cell-permeable allosteric inhibitor of the PTP1B (protein tyrosine phosphatase 1B) enzyme.
Numero CAS: 765317-72-4
Purezza: ≥95%
Peso molecolare: 741.5
Formula molecolare: C26H19Br2N3O7S3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

PTP1B Inhibitor blocks the activity of the Protein Tyrosine Phosphatase 1B, which is a key factor in the negative regulation of insulin and leptin signaling pathway. Molecular dynamic studies have shown that PTP1B Inhibitor has strong binding and high selectivity due to the hydrogen bonding networks formed around the active sites. Cytotoxicity and low revival rates throughout clone generation and maintence result if PTP1B is over-expressed in CHO and HEK293 stable cell clones. Studies have shown that PTP1B Inhibitor could dramatically magnify the membrane translocation of the key glucose transporter Glut4 in PTP1B-overexpressed CHO cells. PTP1B Inhibitor selectively increases the phosphorylation of the insulin receptor, insulin receptor substrate 1, and Akt, mimicking the action of insulin. PTP1B Inhibitor is also known as Protein Tyrosine Phosphatase 1B Inhibitor, and 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-6-benzofuransulfonamide.


Referenze

1. Sun, T., et al. 2007. Chembiochem. 8: 187-193. PMID: 17183521

2. Wang, J.F., et al. 2009. Protein Eng. Des. Sel. 22: 349-355. PMID: 19380334

3. Xu, J.Q., et al. 2010. Bioorg. Med. Chem. 18: 3934-3939. PMID: 20472439

4. Sundaram, S., et al. 2010. Mol. Biol. 44: 535-540. PMID: 20608179

5. Hughes, S.K. et al. 2015. Mol. Biol. Cell. 26(21): 3867-3878. PMID: 26337385

Stato fisico :
Solid
Solubilità :
Soluble in DMSO, and ethanol.
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
855° C at 760 mmHg
Densità :
1.81 g/cm3
Indice di rifrazione :
n20D 1.73
IC50 :
PTP1B403: IC50 = 4 µM; PTP1B298: IC50 = 8 µM
Valori pK :
pKa: 4.47 (Predicted), pKb: 1.70 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
Numero MDL :
MFCD09037556
SMILES :
CCC1=C(C2=C(O1)C=C(C=C2)S(=O)(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CS4)C(=O)C5=CC(=C(C(=C5)Br)O)Br

Download SDS (MSDS)

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PTP1B Inhibitor Inibitore (CAS 765317-72-4)  Citazioni prodotti

Vedi quanti altri hanno usato PTP1B Inhibitor Inibitore (CAS 765317-72-4). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a7 di 7 totali

PMID: # 27016479  Chiba, T. et al. 2016. Biochemical and biophysical research communications. 473: 323-8.

PMID: # 27095436  Song, GJ. et al. 2016. J Neuroinflammation. 13: 86.

PMID: # 26453921  Zhang, H. et al. 2015. Free radical biology & medicine. 89: 701-7.

PMID: # 24519936  Shi, L. et al. 2014. The Journal of biological chemistry. 289: 8432-41.

PMID: # 22903352  Vota, DM. et al. 2013. Cell biochemistry and biophysics. 65: 145-57.

PMID: # 23951017  Zhang, J. et al. 2013. PloS one. 8: e70828.

PMID: # 29742155  PLoS Pathog. e1007054.

Ciatazioni 1 a7 di 7 totali
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