PTP Inhibitor V, PHPS1 CAS: 314291-83-3
MF: C21H15N5O6S
MW: 465.45
A cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2.

PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

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Nomi alternativi: PhenylHydrazonoPyrazolone Sulfonate 1
Applicazione: PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2
Numero CAS: 314291-83-3
Purezza: ≥95%
Peso molecolare: 465.45
Formula molecolare: C21H15N5O6S
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.


Referenze

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

Utilizzo :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (10 mg/ml).
CONSERVAZIONE :
Store at 4° C
IC50 :
Shp-2: IC50 = 2.1 µM; EC50PTP: IC50 = 5.4 µM; PTP1B: IC50 = 19 µM; Shp1: IC50 = 30 µM; mycobacterium MptpA: IC50 = 39 µM
Ki Data :
Shp-2: Ki= 0.73 µM
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
SMILES :
[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

Download SDS (MSDS)

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PTP Inhibitor V, PHPS1 (CAS 314291-83-3)  Citazioni prodotti

Vedi quanti altri hanno usato PTP Inhibitor V, PHPS1 (CAS 314291-83-3). Clicca sulla voce per laccesso a PubMed .

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PMID: # 30776010  Chen, CD. et al. 2019. J. Alzheimers Dis. 67: 1089-1106.

PMID: # 23189174  Tsang, YH. et al. 2012. PLoS ONE. 7: -.

PMID: # 22878065  Gupta, VK. et al. 2012. Biochim. Biophys. Acta. 1822: 1643-9.

PMID: # 31598397  Am J Cancer Res. 9: 1957-1969.

PMID: # 32054954  Sci Rep. 10: 2505.

PMID: # 27812544  JCI Insight. 1: e89020.

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