OX2 Antibody (6A387): sc-71764
- OX2 Antibody (6A387) is a rat monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- raised against CD200 of mouse origin
- recommended for detection of OX2 a cell surface antigen of mouse origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for OX2 Antibody (6A387). This work is in progress.
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OX2 Antibody (6A387) is a rat monoclonal IgG2a antibody that detects OX2 in mouse samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). OX2, also known as CD200, is a critical member of the immunoglobulin superfamily, functioning as a cell surface glycoprotein that plays a significant role in modulating immune responses. This 248-residue protein is predominantly expressed in lymphoid cells, neurons, and endothelial tissues, where OX2 interacts with OX2R to influence inflammatory processes. OX2 (6A387) antibody enables research into pathways that suppress macrophage-induced inflammatory damage through OX2′s engagement with OX2R, which is primarily located in lymphoid and neuronal tissues. Notably, the cytoplasmic domain of OX2R contains NPXY motifs that facilitate interactions with phosphotyrosine-binding (PTB) domains, underscoring OX2′s role in cellular signaling and immune regulation. The extensive N-linked glycosylation of OX2R, accounting for up to 70% of its molecular weight, further highlights the complexity of its structure and implications for receptor function and stability. OX2 (6A387) monoclonal antibody serves as an essential tool for researchers investigating the intricate mechanisms of immune modulation and inflammation in mouse models.
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OX2 Antibody (6A387) References:
- Human CD200 suppresses macrophage-mediated xenogeneic cytotoxicity and phagocytosis. | Sakai, R., et al. 2018. Surg Today. 48: 119-126. PMID: 28573328
- Trophoblast CD200 expression in successful human pregancies and missed abortions. | Clark, DA., et al. 2018. J Reprod Immunol. 127: 55-57. PMID: 29571945
- CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas. | Lawlor, RT., et al. 2019. Virchows Arch. 474: 105-109. PMID: 30132130
- Blockade of macrophage adhesion to CD200-treated polystyrene culture surface. | Zhang, J. and Peng, CA. 2021. J Biomed Mater Res A. 109: 365-373. PMID: 32506802
- CD200 expression marks leukemia stem cells in human AML. | Ho, JM., et al. 2020. Blood Adv. 4: 5402-5413. PMID: 33147339
- The CD200 Regulates Inflammation in Mice Independently of TNF-α Production. | Tonecka, K., et al. 2021. Int J Mol Sci. 22: PMID: 34069671
- The CD200/CD200R mechanism in mesenchymal stem cells' regulation of dendritic cells. | Zhao, Y., et al. 2021. Am J Transl Res. 13: 9607-9613. PMID: 34540085
- Overlap between CD23 and CD200 in leukemic lymphoproliferative disorders. | Güell, N., et al. 2022. Int J Lab Hematol. 44: e149-e152. PMID: 35000272
- Decreased expression of CD200 on peripheral blood leukocytes in alcohol dependence. | Chaturvedi, A., et al. 2023. Alcohol. 113: 21-25. PMID: 37595696
- CD200 genotype is associated with clinical outcome of patients with multiple myeloma. | Gonzalez-Montes, Y., et al. 2024. Front Immunol. 15: 1252445. PMID: 38455039
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OX2 Antibody (6A387) | sc-71764 | 200 µg/ml | $322.00 | |||
OX2 Antibody (6A387) FITC | sc-71764 FITC | 200 µg/ml | $336.00 | |||
OX2 Antibody (6A387) PE | sc-71764 PE | 200 µg/ml | $349.00 |