Neobavaisoflavone CAS: 41060-15-5
MF: C20H18O4
MW: 322.35
A DNA polymerase inhibitor and platelet aggregation inhibitor.

Neobavaisoflavone (CAS 41060-15-5)

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Nomi alternativi: 7-Hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-chromen-4-one
Applicazione: Neobavaisoflavone is a DNA polymerase inhibitor and platelet aggregation inhibitor
Numero CAS: 41060-15-5
Purezza: ≥97%
Peso molecolare: 322.35
Formula molecolare: C20H18O4
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Neobavaisoflavone, an isoflavanone derivative, has been reported to display an anti-fungal capacity in vitro. Studies show that this compound can also capable of inhibiting platelet aggregation in rabbit platelets induced by arachidonic acid in vitro. Additional experiments have noted Neobavaisoflavone to be a DNA polymerase inhibitor and an enhancer of TRIAL-induced apoptosis of cells. TRIAL (tumor necrosis factor-related apoptosis-inducing ligand) is an agent that selectively induces programmed cell death in certain cells.


Referenze

1. Nkengfack, A.E., et al. 1994. Phytochemistry. 36: 1047-1051. PMID: 7765206
2. Tsai, W.J., et al. 1996. J. Nat. Prod. 59: 671-672. PMID: 8759164
3. Sun, N.J., et al. 1998. J. Nat. Prod. 61: 362-366. PMID: 9544566
4. Bronikowska, J., et al. 2010. Molecules. 15: 2000-2015. PMID: 20336028

Stato fisico :
Solid
Derivato da :
plant Psoralea corylifolia
Solubilità :
Soluble in DMSO, and 100% ethanol.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
206.97° C (Predicted)
Punto di ebollizione :
545.01° C at 760 mmHg (Predicted)
Densità :
1.28 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.65 (Predicted)
IC50 :
Platelet-activating factor-induced platelet aggregation : IC50 = 2.5 µM; Arachidonic acid-induced platelet aggregation preincubated : IC50 = 7.8 µM; Melanin synthesis : IC50 = 9.4 µM; Collagen-induced platelet aggregation: IC50 = 62.4 µM
Valori pK :
pKa: 6.92 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
PubChem CID :
Numero MDL :
MFCD00800660
SMILES :
CC(=CCC1=C(C=CC(=C1)C2=COC3=C(C2=O)C=CC(=C3)O)O)C

Download SDS (MSDS)

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