myopalladin Antibody (72-J): sc-81810

myopalladin Antibody (72-J) is a mouse monoclonal IgG1 kappa light chain antibody that detects myopalladin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-myopalladin antibody (72-J) is available as a non-conjugated isotype antibody. Myopalladin, also known as MYPN or MYOP, is a crucial 1,320 amino acid protein that plays a significant role in muscle function by localizing to both the cytoplasm and nucleus. Myopalladin is a member of the myotilin/palladin family and is predominantly expressed in fetal heart and adult skeletal muscle, where myopalladin serves as a vital structural component of the sarcomere, effectively tethering both skeletal and cardiac muscle to α-actinin. Myopalladin features five immunoglobulin-like domains and is anchored within the central I-band region and at the Z-line periphery of the sarcomere. Proper functioning of myopalladin is essential for maintaining sarcomeric integrity, as overexpression can lead to disruptions in sarcomeric function. Notably, defects in the gene encoding myopalladin have been linked to idiopathic dilated cardiomyopathy (DCM), a condition characterized by an enlarged heart that fails to function effectively. Additionally, three isoforms of myopalladin arise from alternative splicing events, further underscoring the complexity and importance of myopalladin in muscle physiology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

myopalladin Antibody (72-J) References:

1. Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.  |  Bang, ML., et al. 2001. J Cell Biol. 153: 413-27. PMID: 11309420
2. Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.  |  Ma, K. and Wang, K. 2002. FEBS Lett. 532: 273-8. PMID: 12482578
3. The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.  |  Miller, MK., et al. 2003. J Mol Biol. 333: 951-64. PMID: 14583192
4. The palladin/myotilin/myopalladin family of actin-associated scaffolds.  |  Otey, CA., et al. 2005. Int Rev Cytol. 246: 31-58. PMID: 16164966
5. Associations of functional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle deposition.  |  Wimmers, K., et al. 2007. Anim Genet. 38: 474-84. PMID: 17697135
6. Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy.  |  Duboscq-Bidot, L., et al. 2008. Cardiovasc Res. 77: 118-25. PMID: 18006477

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-myopalladin Antibody (72-J) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-myopalladin Antibody (72-J) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

myopalladin Antibody (72-J) Specifications

Alternate Product Name: myopalladin

Product Clone Name: 72-J

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 61-171

Epitope Target: myopalladin

Epitope Species: human

Product Reactivity/Detection: myopalladin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for myopalladin Antibody (72-J): N/A