LAIR-1 Antibody (D-11): sc-393550

LAIR-1 Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects leukocyte-associated Ig-like receptor-1 (LAIR-1) in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LAIR-1 is a transmembrane glycoprotein predominantly expressed on human peripheral blood mononuclear leukocytes, playing a crucial role in immune regulation. LAIR-1 is located on the cell surface, where LAIR-1 functions as an inhibitory receptor that modulates immune responses by recruiting SHP-1, a phosphatase that negatively regulates cell signaling pathways. This interaction is vital for maintaining the balance of immune activation and inhibition, particularly in T lymphocytes, where LAIR-1 helps establish signaling thresholds that prevent overactivation. Notably, LAIR-1 phosphorylation at specific tyrosine residues, such as Tyr 233 and Tyr 263, is essential for function, as phosphorylation facilitates SHP-1 recruitment and influences downstream signaling events. LAIR-1′s ability to inhibit proliferation and induce programmed cell death in myelomonocytic leukemic cell lines underscores LAIR-1′s importance in regulating immune cell behavior. Furthermore, LAIR-1 cross-linking on natural killer cells significantly dampens cytotoxic activity, highlighting LAIR-1′s role in modulating immune responses. LAIR-1 (D-11) antibody is an invaluable tool for researchers studying immune regulation and signaling mechanisms involved in leukocyte function.

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LAIR-1 Antibody (D-11) References:

1. LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells.  |  Meyaard, L. 1999. Curr Top Microbiol Immunol. 244: 151-7. PMID: 10453657
2. A non-stimulatory monoclonal antibody against the inhibitory immunoreceptor LAIR-1.  |  Xie, X., et al. 2014. Monoclon Antib Immunodiagn Immunother. 33: 141-7. PMID: 24694245
3. Comparison of LAIR-1 genetic pathways in murine vs human internal organs.  |  Sun, S., et al. 2014. Gene. 552: 140-5. PMID: 25234728
4. Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.  |  Smith, CW., et al. 2017. Arterioscler Thromb Vasc Biol. 37: 823-835. PMID: 28336561
5. Silencing LAIR-1 in human THP-1 macrophage increases foam cell formation by modulating PPARγ and M2 polarization.  |  Yi, X., et al. 2018. Cytokine. 111: 194-205. PMID: 30176557
6. LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.  |  Liu, Y., et al. 2020. Aging (Albany NY). 12: 16142-16154. PMID: 32628130
7. Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1.  |  Keerthivasan, S., et al. 2021. Immunity. 54: 1511-1526.e8. PMID: 34260887
8. 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis.  |  Myers, LK., et al. 2021. Int J Mol Sci. 22: PMID: 34948139
9. A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR-1 mediated mitochondrial dysfunction and apoptosis.  |  Ma, L., et al. 2023. Environ Toxicol. 38: 1118-1132. PMID: 36810933
10. Efficient delivery of the lncRNA LEF1-AS1 through the antibody LAIR-1 (CD305)-modified Zn-Adenine targets articular inflammation to enhance the treatment of rheumatoid arthritis.  |  Zhang, X., et al. 2023. Arthritis Res Ther. 25: 238. PMID: 38062469

The preferred LAIR-1 antibody is LAIR-1 Antibody (F-5): sc-398141.