IRF-1 Antibody (F-2): sc-514505

IRF-1 Antibody (F-2) is a mouse monoclonal IgM antibody that detects interferon regulatory factor-1 (IRF-1) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IRF-1 plays a crucial role in the immune response by acting as a transcriptional activator for type I interferon genes, which are essential for antiviral response and regulation of immune cell functions. IRF-1 is primarily located in the nucleus, where IRF-1 binds to specific DNA sequences in the promoters of interferon-α and interferon-β genes, facilitating transcription. Nuclear localization allows IRF-1 to exert regulatory effects on gene expression in response to viral infections and other immune stimuli. IRF-1′s ability to interact with other members of the interferon regulatory factor family, such as IRF-2, highlights IRF-1′s importance in maintaining a balance between activation and repression of immune responses, which is critical for preventing excessive inflammation and autoimmunity. Anti-IRF-1 antibody (F-2) serves as an invaluable tool for researchers studying immune regulation mechanisms and interferon signaling′s role in various diseases.

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IRF-1 Antibody (F-2) References:

1. IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal.  |  Sun, C., et al. 2012. Circ Res. 111: 1054-64. PMID: 22874466
2. IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation.  |  Sudhakar, C., et al. 2013. Biochem Biophys Res Commun. 437: 179-84. PMID: 23811275
3. IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production.  |  Yokota, S., et al. 2015. J Immunol. 194: 6045-56. PMID: 25964490
4. TRIM14 expression is regulated by IRF-1 and IRF-2.  |  Cui, J., et al. 2019. FEBS Open Bio. 9: 1413-1420. PMID: 31150153
5. Interferon regulatory factor 1 (IRF-1) and IRF-2 regulate PD-L1 expression in hepatocellular carcinoma (HCC) cells.  |  Yan, Y., et al. 2020. Cancer Immunol Immunother. 69: 1891-1903. PMID: 32377817
6. IRF-1 Inhibits Angiogenic Activity of HPV16 E6 Oncoprotein in Cervical Cancer.  |  Rho, SB., et al. 2020. Int J Mol Sci. 21: PMID: 33076322
7. Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells.  |  Yan, Y., et al. 2021. Br J Cancer. 125: 101-111. PMID: 33772151
8. Autophagic activation of IRF-1 aggravates hepatic ischemia-reperfusion injury via JNK signaling.  |  Li, S., et al. 2021. MedComm (2020). 2: 91-100. PMID: 34766137
9. Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.  |  Saffari, M., et al. 2022. Infect Genet Evol. 103: 105337. PMID: 35835355
10. Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection.  |  Schmalzl, A., et al. 2022. Nat Commun. 13: 5730. PMID: 36175404

The preferred IRF-1 antibody is IRF-1 Antibody (H-8): sc-74530.