IRE1 alpha Antibody (YB-17): sc-100772
- IRE1α Antibody (YB-17) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant IRE1α of human origin
- recommended for detection of IRE1α of human origin by WB, IP, IF and ELISA
- See IRE1α (B-12): sc-390960 for IRE1α antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IRE1α Antibody (YB-17). This work is in progress.
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IRE1α Antibody (YB-17) is a mouse monoclonal IgG2a antibody that detects IRE1α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRE1α plays a crucial role in the unfolded protein response (UPR), a cellular stress response activated when unfolded proteins accumulate in the endoplasmic reticulum (ER). IRE1α is primarily located in the ER lumen, where IRE1α functions as a sensor for ER stress, initiating a cascade of signaling events that help restore cellular homeostasis. IRE1α′s location is crucial for oligomerization and trans-phosphorylation in response to stress, which enhances intrinsic kinase activity and leads to the transcription of genes aiding in protein folding and degradation. Through facilitating proper UPR functioning, IRE1α is essential for maintaining cellular health and preventing diseases associated with protein misfolding, such as neurodegenerative disorders and diabetes. Anti-IRE1α antibody (YB-17) serves as an invaluable tool for researchers studying these critical pathways and their implications in human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IRE1 alpha Antibody (YB-17) References:
- IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. | Song, M., et al. 2018. Nature. 562: 423-428. PMID: 30305738
- IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. | He, S., et al. 2021. J Clin Invest. 131: PMID: 34283807
- Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis. | Chen, Y., et al. 2022. Nat Metab. 4: 1166-1184. PMID: 36123394
- Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis. | Jing, G., et al. 2022. J Neuroinflammation. 19: 237. PMID: 36171629
- MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α. | Kovaleva, V., et al. 2023. Cell Rep. 42: 112066. PMID: 36739529
- Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction. | Smolgovsky, S., et al. 2023. J Clin Invest. 133: PMID: 37874641
- Hepatic IRE1α-XBP1 signaling promotes GDF15-mediated anorexia and body weight loss in chemotherapy. | Tang, Y., et al. 2024. J Exp Med. 221: PMID: 38695876
- Mammalian IRE1α dynamically and functionally coalesces with stress granules. | Liu, S., et al. 2024. Nat Cell Biol. 26: 917-931. PMID: 38714852
- IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis. | Jiang, D., et al. 2024. Nat Commun. 15: 4114. PMID: 38750057
- IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer. | Xu, L., et al. 2024. Cell. 187: 7248-7266.e34. PMID: 39419025
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRE1α Antibody (YB-17) | sc-100772 | 100 µg/ml | $339.00 |