IGF2BP3 Antibody (G-9): sc-376067

IGF2BP3 Antibody (G-9) is a mouse monoclonal IgG2a antibody that detects IGF2BP3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IGF2BP3, also known as insulin-like growth factor II mRNA-binding protein 3, plays a critical role in regulating mRNA stability and translation, which is essential for cellular growth and differentiation. IGF2BP3 is predominantly located in the cytoplasm, where IGF2BP3 binds to specific mRNAs, including those of IGF-II and c-Myc, thereby influencing their stability and translation efficiency. IGF2BP3′s cytoplasmic localization allows for rapid responses to cellular signals, particularly in cancer cells, where IGF2BP3 expression is often upregulated. Elevated levels of IGF2BP3 have been associated with various malignancies, including pancreatic ductal adenocarcinoma, making IGF2BP3 a valuable biomarker for cancer diagnosis and prognosis. Anti-IGF2BP3 antibody (G-9) provides a reliable tool for researchers investigating IGF2BP3′s role in cancer biology and other cellular processes.

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IGF2BP3 Antibody (G-9) References:

1. IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis.  |  Zhou, Y., et al. 2017. Mol Cancer. 16: 77. PMID: 28399871
2. IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer.  |  Huang, W., et al. 2020. J Cell Mol Med. 24: 13949-13960. PMID: 33094561
3. Abnormal Expression of N6-Methyladenosine RNA Methylation Regulator IGF2BP3 in Colon Cancer Predicts a Poor Prognosis.  |  Wu, T., et al. 2022. Dis Markers. 2022: 5883101. PMID: 35677634
4. RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.  |  Jiang, T., et al. 2022. FASEB J. 36: e22618. PMID: 36250924
5. STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.  |  Zhang, X., et al. 2023. J Exp Clin Cancer Res. 42: 19. PMID: 36639675
6. LncRNA FOXD3-AS1/miR-128-3p axis-mediated IGF2BP3 in glioma stimulates cancer angiogenesis and progression.  |  Zhao, H., et al. 2023. Folia Neuropathol. 61: 168-184. PMID: 37587892
7. RNA N6-methyladenosine reader IGF2BP3 promotes acute myeloid leukemia progression by controlling stabilization of EPOR mRNA.  |  Fan, J., et al. 2023. PeerJ. 11: e15706. PMID: 37663284
8. Disrupting of IGF2BP3-stabilized HK2 mRNA by MYO16-AS1 competitively binding impairs LUAD migration and invasion.  |  Li, P., et al. 2024. Mol Cell Biochem. 479: 2795-2808. PMID: 38041756
9. Epigenetically associated IGF2BP3 upregulation promotes cell proliferation by regulating E2F1 expression in hepatocellular carcinoma.  |  Liu, C., et al. 2024. Sci Rep. 14: 16051. PMID: 38992083
10. Stabilization of SQLE mRNA by WTAP/FTO/IGF2BP3-dependent manner in HGSOC: implications for metabolism, stemness, and progression.  |  Hou, R., et al. 2024. Cell Death Dis. 15: 872. PMID: 39617776

The preferred IGF2BP3 antibody is IGF2BP3 Antibody (E-2): sc-365640.