HPV18 E6 Antibody (289-13965): sc-57835

HPV18 E6 Antibody (289-13965) is a mouse monoclonal IgG1 antibody that detects HPV18 E6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). HPV18 E6 plays a crucial role in the oncogenic process associated with high-risk human papillomavirus infections, particularly in cervical cancer. HPV18 E6 functions primarily by binding to the tumor suppressor protein p53, leading to its degradation and disruption of normal cell cycle regulation. The ability of HPV18 E6 to inactivate p53 is significant because p53 is often referred to as the "guardian of the genome," as p53 helps prevent the proliferation of cells with damaged DNA. By evading the protective effects of p53, HPV18 E6 contributes to the accumulation of genetic mutations and cancer progression. Anti-HPV18 E6 antibody (289-13965) is essential for researchers studying the molecular mechanisms of HPV-related carcinogenesis and can aid in developing targeted therapies and diagnostic tools for HPV-associated malignancies.

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HPV18 E6 Antibody (289-13965) References:

1. Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cells.  |  Chen, TM. and Defendi, V. 1992. Oncogene. 7: 1541-7. PMID: 1321402
2. HPV18 E6 and E7 genes affect cell cycle, pRB and p53 of cervical tumor cells and represent prominent candidates for intervention by use peptide nucleic acids (PNAs).  |  Braun, K., et al. 2004. Cancer Lett. 209: 37-49. PMID: 15145519
3. Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression.  |  Zhang, KJ., et al. 2009. Acta Pharmacol Sin. 30: 153-8. PMID: 19122673
4. Construction and identification of a yeast two-hybrid bait vector and its effect on the growth of yeast cells and the self-activating function of reporter genes for screening of HPV18 E6-interacting protein.  |  Mei, Q., et al. 2010. J Huazhong Univ Sci Technolog Med Sci. 30: 8-12. PMID: 20155448
5. Down-regulation of HPV18 E6, E7, or VEGF expression attenuates malignant biological behavior of human cervical cancer cells.  |  Chen, L., et al. 2011. Med Oncol. 28 Suppl 1: S528-39. PMID: 21222176
6. Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging.  |  Li, JM., et al. 2011. Biomaterials. 32: 7978-87. PMID: 21784514
7. SAHA inhibits the transcription initiation of HPV18 E6/E7 genes in HeLa cervical cancer cells.  |  He, H., et al. 2014. Gene. 553: 98-104. PMID: 25300249
8. Tip60 and p300 function antagonistically in the epigenetic regulation of HPV18 E6/E7 genes in cervical cancer HeLa cells.  |  Lai, Y., et al. 2020. Genes Genomics. 42: 691-698. PMID: 32399935
9. Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells.  |  Tian, R., et al. 2022. Mol Ther Oncolytics. 24: 171-179. PMID: 35036522
10. MicroRNA-130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2.  |  Yin, S., et al. 2022. Exp Ther Med. 23: 316. PMID: 35371299

The preferred HPV16 E6/18 E6 antibody is HPV16 E6/18 E6 Antibody (C1P5): sc-460.