GM-CSFRα Antibody (4H1): sc-21764

GM-CSFRα Antibody (4H1) is a mouse monoclonal IgG1 antibody that detects GM-CSFRα in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). GM-CSFRα, or Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha, plays a crucial role in hematopoiesis and immune response by mediating the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), which is essential for the proliferation, differentiation, and survival of myeloid cells. GM-CSFRα is primarily located on the surface of hematopoietic cells, where GM-CSFRα forms a functional receptor complex with the common β subunit, enabling high-affinity binding to GM-CSF. This interaction is vital for the activation of downstream signaling pathways that promote cell survival and proliferation, highlighting GM-CSFRα′s importance in maintaining immune homeostasis and responding to inflammatory stimuli. Anti-GM-CSFRα antibody (4H1) serves as an invaluable tool for researchers studying the role of GM-CSF in various physiological and pathological processes, including implications in cancer, autoimmune diseases, and other immune disorders.

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GM-CSFRα Antibody (4H1) References:

1. Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1.  |  Martinez-Moczygemba, M., et al. 2008. J Exp Med. 205: 2711-6. PMID: 18955567
2. Mechanistic modeling of antigen sink effect for mavrilimumab following intravenous administration in patients with rheumatoid arthritis.  |  Wang, B., et al. 2012. J Clin Pharmacol. 52: 1150-61. PMID: 21947370
3. GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia.  |  Parajuli, B., et al. 2012. J Neuroinflammation. 9: 268. PMID: 23234315
4. Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.  |  Sawada, H., et al. 2014. J Exp Med. 211: 263-80. PMID: 24446489
5. Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis.  |  Greven, DE., et al. 2015. Ann Rheum Dis. 74: 1924-30. PMID: 24936585
6. GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential.  |  Hamilton, JA. 2015. Expert Rev Clin Immunol. 11: 457-65. PMID: 25748625
7. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS).  |  Li, Y., et al. 2017. Neurourol Urodyn. 36: 1020-1025. PMID: 27337494
8. The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation.  |  Matsuguchi, T., et al. 1997. J Biol Chem. 272: 17450-9. PMID: 9211889
9. IL-3, IL-5, granulocyte-macrophage colony-stimulating factor receptor alpha-subunit, and common beta-subunit expression by peripheral leukocytes and blood dendritic cells.  |  Yamada, T., et al. 1998. J Allergy Clin Immunol. 101: 677-82. PMID: 9600506

The preferred GM-CSFRα antibody is GM-CSFRα Antibody (S-50): sc-456.