GluR-δ2 Antibody (48): sc-135927
- GluR-δ2 Antibody (48) is a mouse monoclonal IgG1 provided at 50 µg/500 µl
- raised against amino acids 665-786 of GluR-δ2 of mouse origin
- recommended for detection of GluR-δ2 of mouse and rat origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GluR-δ2 Antibody (48). This work is in progress.
GluR-δ2 Antibody (48) is a mouse monoclonal IgG1 antibody that detects GluR-δ2 in mouse and rat samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. GluR-δ2 is a crucial component of the kainate/AMPA receptor family, which plays a significant role in mediating fast excitatory neurotransmission in the brain. GluR-δ2 is primarily located in the synaptic membranes of neurons, where GluR-δ2 contributes to synaptic plasticity and the modulation of synaptic strength, essential for learning and memory processes. GluR-δ2′s presence in the brainstem is particularly important, as GluR-δ2 is involved in the regulation of various neural circuits that govern motor control and sensory processing. Notably, mutations in the gene encoding GluR-δ2 (GRID2) have been linked to the Lurcher phenotype in mice, highlighting GluR-δ2′s critical role in maintaining normal neural function. The human counterpart of GluR-δ2 is located on chromosome 4q22, and understanding GluR-δ2′s interactions and functions can provide insights into neurodevelopmental disorders and neurodegenerative diseases. Anti-GluR-δ2 antibody (48) is an invaluable tool for researchers investigating the dynamics of excitatory neurotransmission and the underlying mechanisms of synaptic plasticity.
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GluR-δ2 Antibody (48) References:
- Direct interaction of GluRdelta2 with Shank scaffold proteins in cerebellar Purkinje cells. | Uemura, T., et al. 2004. Mol Cell Neurosci. 26: 330-41. PMID: 15207857
- Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluRdelta2 knock-out mouse. | Ohtsuki, G., et al. 2004. J Neurosci. 24: 10900-7. PMID: 15574740
- CRF and urocortin differentially modulate GluRdelta2 expression and distribution in parallel fiber-Purkinje cell synapses. | Gounko, NV., et al. 2005. Mol Cell Neurosci. 30: 513-22. PMID: 16198122
- Cerebellar regulation mechanisms learned from studies on GluRdelta2. | Hirano, T. 2006. Mol Neurobiol. 33: 1-16. PMID: 16388107
- The extreme C-terminus of GluRdelta2 is essential for induction of long-term depression in cerebellar slices. | Kohda, K., et al. 2007. Eur J Neurosci. 25: 1357-62. PMID: 17425562
- Glutamate-receptor-like molecule GluRδ2 involved in synapse formation at parallel fiber-Purkinje neuron synapses. | Hirano, T. 2012. Cerebellum. 11: 71-7. PMID: 20387025
- Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. | Uemura, T., et al. 2010. Cell. 141: 1068-79. PMID: 20537373
- Development of an anatomical technique for visualizing the mode of climbing fiber innervation in Purkinje cells and its application to mutant mice lacking GluRδ2 and Ca(v)2.1. | Miyazaki, T. and Watanabe, M. 2011. Anat Sci Int. 86: 10-8. PMID: 21153457
- GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation. | Lee, SJ., et al. 2012. J Neurosci. 32: 4688-701. PMID: 22457515
- Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse. | Hashizume, M., et al. 2013. Front Neural Circuits. 7: 130. PMID: 23970854
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GluR-δ2 Antibody (48) | sc-135927 | 50 µg/500 µl | $322.00 |