Ep-CAM Antibody (0.N.277): sc-59782

Ep-CAM Antibody (0.N.277) is a mouse monoclonal IgG1 antibody that detects Ep-CAM in mouse, rat, and human samples through applications such as western blotting (WB) (non-reducing), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Ep-CAM, also known as tumor-associated calcium signal transducer 1 and MK-1, is a monomeric membrane glycoprotein predominantly expressed in normal human epithelial tissues and various carcinomas, making Ep-CAM a significant marker for cancer research. Anti-Ep-CAM antibody (0.N.277) recognizes a protein that plays a crucial role in cell adhesion, which is vital for maintaining tissue integrity and regulating cellular signaling pathways. Ep-CAM′s extracellular domain features two epidermal growth factor-like repeats and a cysteine-poor region, both of which are essential for adhesive properties. Notably, Ep-CAM is often overexpressed in a range of solid tumors, highlighting Ep-CAM′s potential as a therapeutic target and a biomarker for cancer diagnosis and treatment. The human Ep-CAM gene encodes a 314 amino acid protein that exists in two forms, with the major form being more prevalent; treatment with the amino-glycosylation inhibitor tunicamycin reduces the expression of both forms. Ep-CAM monoclonal antibody (0.N.277) is an invaluable tool for researchers aiming to explore Ep-CAM′s role in cancer biology and potential applications in targeted therapies.

The preferred Ep-CAM antibody is Ep-CAM Antibody (C-10): sc-25308.