dUTPase Antibody (F-6): sc-166758
- dUTPase Antibody (F-6) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 203-219 near the C-terminus of dUTPase of human origin
- recommended for detection of dUTPase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for dUTPase Antibody (F-6) for WB applications. These reagents are now offered in bundles with dUTPase Antibody (F-6) (see ordering information below).
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SEE ALSO...
dUTPase Antibody (F-6) is a mouse monoclonal IgG2a antibody that detects dUTPase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). dUTPase, also known as deoxyuridine 5′-triphosphate nucleotidohydrolase or DUT, plays a critical role in nucleotide metabolism as a preventive DNA repair enzyme, ensuring genetic material integrity. DUT-N, the nuclear isoform, remains most abundant and crucial for maintaining low intracellular dUTP concentrations. dUTPase hydrolyzes dUTP to dUMP and diphosphate with magnesium ions, preventing uracil incorporation into DNA, which can lead to mutations and cell death. dUTPase′s role in cellular viability highlights potential anticancer therapy applications, as inhibiting dUTPase function could disrupt DNA replication and repair processes. dUMP, produced through hydrolysis, serves as a precursor for thymidine nucleotides essential for DNA synthesis, underscoring dUTPase′s vital role in cellular proliferation and genomic stability.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
dUTPase Antibody (F-6) | sc-166758 | 200 µg/ml | $322.00 | |||
dUTPase Antibody (F-6): m-IgGκ BP-HRP Bundle | sc-534820 | 200 µg Ab; 40 µg BP | $361.00 | |||
dUTPase Antibody (F-6): m-IgG2a BP-HRP Bundle | sc-546197 | 200 µg Ab; 10 µg BP | $361.00 | |||
dUTPase (F-6) Neutralizing Peptide | sc-166758 P | 100 µg/0.5 ml | $69.00 |