Daxx Antibody (6D345): sc-70952

Daxx Antibody (6D345) is a mouse monoclonal IgG1 antibody that detects Daxx in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Daxx plays a crucial role in the regulation of apoptosis, particularly in the context of the FAS signaling pathway, which is essential for maintaining immune system balance and tissue homeostasis. Daxx is primarily located in the nucleus and cytoplasm of cells, where anti-Daxx antibody (6D345) can detect its function as a scaffold for various signaling molecules, thereby influencing cellular responses to stress and death signals. The subcellular localization of Daxx is significant because Daxx allows for the integration of multiple signaling pathways, facilitating the activation of Jun N-terminal kinase (JNK) and promoting apoptosis in response to FAS ligand binding. Notably, Daxx interacts with the death domain of the FAS receptor, despite lacking a death domain itself, highlighting Daxx′s unique role in apoptosis regulation. The Daxx-mediated apoptotic pathway is distinct yet cooperative with other pathways, such as the FAS-FADD-FLICE pathway, and is sensitive to the apoptotic inhibitor protein Bcl-2, making Daxx a critical player in the complex network of apoptosis regulation. Daxx (6D345) antibody is an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer and autoimmune disorders.

The preferred Daxx antibody is Daxx Antibody (H-7): sc-8043.