Daxx Antibody (6D345): sc-70952
- Daxx Antibody (6D345) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 558-740 of Daxx of human origin
- recommended for detection of Daxx of human origin by WB, IP and IF
- See Daxx (H-7): sc-8043 for Daxx antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Daxx Antibody (6D345). This work is in progress.
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Daxx Antibody (6D345) is a mouse monoclonal IgG1 antibody that detects Daxx in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Daxx plays a crucial role in the regulation of apoptosis, particularly in the context of the FAS signaling pathway, which is essential for maintaining immune system balance and tissue homeostasis. Daxx is primarily located in the nucleus and cytoplasm of cells, where anti-Daxx antibody (6D345) can detect its function as a scaffold for various signaling molecules, thereby influencing cellular responses to stress and death signals. The subcellular localization of Daxx is significant because Daxx allows for the integration of multiple signaling pathways, facilitating the activation of Jun N-terminal kinase (JNK) and promoting apoptosis in response to FAS ligand binding. Notably, Daxx interacts with the death domain of the FAS receptor, despite lacking a death domain itself, highlighting Daxx′s unique role in apoptosis regulation. The Daxx-mediated apoptotic pathway is distinct yet cooperative with other pathways, such as the FAS-FADD-FLICE pathway, and is sensitive to the apoptotic inhibitor protein Bcl-2, making Daxx a critical player in the complex network of apoptosis regulation. Daxx (6D345) antibody is an invaluable tool for researchers studying apoptosis and its implications in various diseases, including cancer and autoimmune disorders.
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Daxx Antibody (6D345) References:
- Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization. | Shih, HM., et al. 2007. Biochem Soc Trans. 35: 1397-400. PMID: 18031230
- SUMmOning Daxx-mediated repression. | Mukhopadhyay, D. and Matunis, MJ. 2011. Mol Cell. 42: 4-5. PMID: 21474063
- Subcellular localization of DAXX influence ox-LDL induced apoptosis in macrophages. | Xiong, G., et al. 2014. Mol Biol Rep. 41: 7183-90. PMID: 25120166
- Death domain associated protein (Daxx), a multi-functional protein. | Tang, SY., et al. 2015. Cell Mol Biol Lett. 20: 788-97. PMID: 26540225
- Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs. | Ueda, H., et al. 2018. Endocr Relat Cancer. 25: 619-631. PMID: 29599123
- Histone H3F3/H3.3 chaperone DAXX converts to modulate SQSTM1 phase condensation for NFE2L2 activation. | Yang, Y., et al. 2020. Autophagy. 16: 171-172. PMID: 31607206
- Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation. | Groh, S., et al. 2021. Nat Commun. 12: 5996. PMID: 34650047
- Reciprocal regulation of Daxx and PIK3CA promotes colorectal cancer cell growth. | Huang, YS., et al. 2022. Cell Mol Life Sci. 79: 367. PMID: 35718818
- Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein. | Jelinska, C., et al. 2023. RSC Chem Biol. 4: 1096-1110. PMID: 38033728
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Daxx Antibody (6D345) | sc-70952 | 100 µg/ml | $322.00 |