Date published: 2026-4-24

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Amisulpride (CAS 71675-85-9)

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Alternate Names:
4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulf onyl)-2-benzamide DAN 2163
Application:
Amisulpride is a selective D2DR and D3DR inhibitor
CAS Number:
71675-85-9
Purity:
≥99%
Molecular Weight:
369.48
Molecular Formula:
C17H27N3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Amisulpride is a compound used in research models to explore its interaction with dopamine receptors and the resulting effects on neurotransmitter pathways. In neurochemical studies, amisulpride is known for its high affinity for D2 and D3 dopamine receptor subtypes. Research involving amisulpride focuses on understanding the modulation of dopaminergic systems, which are implicated in regulating mood, motivation, and reward processes. In certain models, amisulpride is used to investigate the effects of altered dopamine receptor activity on behavior and to model conditions where dopamine modulation is a key factor. Furthermore, amisulpride is applied in receptor binding assays to quantify the presence and density of dopamine receptors in various tissues. Its selectivity for dopaminergic receptors makes it useful for dissecting the roles of specific receptor subtypes in physiological and pathological processes within the central nervous system.


Amisulpride (CAS 71675-85-9) References

  1. Amisulpride promotes cognitive flexibility in rats: the role of 5-HT7 receptors.  |  Nikiforuk, A. and Popik, P. 2013. Behav Brain Res. 248: 136-40. PMID: 23603557
  2. Amisulpride as add-on treatment for resistant obsessive-compulsive disorder: retrospective case series.  |  Miodownik, C., et al. 2015. Clin Neuropharmacol. 38: 26-9. PMID: 25580923
  3. Amisulpride: A New Dopamine Antagonist for Treatment of Postoperative Nausea and Vomiting.  |  Gan, TJ. and Mouch, CM. 2019. Anesth Analg. 128: 1074-1076. PMID: 31094771
  4. Amisulpride: Real-World Evidence of Dose Adaptation and Effect on Prolactin Concentrations and Body Weight Gain by Pharmacokinetic/Pharmacodynamic Analyses.  |  Glatard, A., et al. 2020. Clin Pharmacokinet. 59: 371-382. PMID: 31552612
  5. Microenvironmental pH-modified Amisulpride-Labrasol matrix tablets: development, optimization and in vivo pharmacokinetic study.  |  Younes, NF., et al. 2021. Drug Deliv Transl Res. 11: 103-117. PMID: 31900797
  6. Efficacy of amisulpride on postoperative nausea and vomiting: a systematic review and meta-analysis.  |  Zhang, LF., et al. 2020. Eur J Clin Pharmacol. 76: 903-912. PMID: 32274525
  7. Comparative cost-effectiveness of amisulpride and olanzapine in the treatment of schizophrenia in China.  |  Yi, ZM., et al. 2020. Expert Rev Pharmacoecon Outcomes Res. 20: 313-320. PMID: 32293194
  8. Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway.  |  Mohamed, AM., et al. 2020. Eur J Pharmacol. 885: 173411. PMID: 32800810
  9. Occurrence of macroprolactinemia in schizophrenia patients treated with risperidone or amisulpride.  |  Zhenhua, W., et al. 2022. Asia Pac Psychiatry. 14: e12469. PMID: 33754473
  10. Amisulpride: A Useful Second-Generation Antipsychotic Omitted From the US Residency Training Curriculum.  |  Gupta, M. 2021. Prim Care Companion CNS Disord. 23: PMID: 34738352
  11. Amisulpride withdrawal akathisia responding to aripiprazole with propranolol in first-onset psychosis: a case report.  |  Yang, HJ., et al. 2022. BMC Psychiatry. 22: 74. PMID: 35093063
  12. When to Use Amisulpride in Adolescents: A Retrospective Chart Examination of Inpatients.  |  Tuncturk, M., et al. J Clin Psychopharmacol. 42: 247-253. PMID: 35149609
  13. Amisulpride steady-state plasma concentration and adverse reactions in patients with schizophrenia: a study based on therapeutic drug monitoring data.  |  Qu, K., et al. 2022. Int Clin Psychopharmacol. 37: 255-262. PMID: 35779068

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Amisulpride, 50 mg

sc-203510
50 mg
$116.00