Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11): sc-398776
- Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 262-287 within an internal region of ALDH4A1 of human origin
- recommended for detection of ALDH4A1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11) for WB applications. These reagents are now offered in bundles with Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11) (see ordering information below).
ALDH4A1 Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects ALDH4A1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALDH4A1, also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), plays a crucial role in the proline degradation pathway by catalyzing the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate within the mitochondrial matrix. This enzymatic activity is vital for maintaining cellular homeostasis and regulating proline levels, which are essential for various metabolic processes, including energy production and neurotransmitter synthesis. Dysregulation of ALDH4A1 due to genetic mutations can lead to hyperprolinemia type II, a condition marked by elevated levels of proline and P5C, which can result in severe neurological consequences such as mental retardation and seizures. ALDH4A1 (E-11) antibody serves as an invaluable tool for researchers investigating the role of this enzyme in metabolic disorders and its potential implications in neurological health.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11) | sc-398776 | 200 µg/ml | $322.00 | |||
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-538521 | 200 µg Ab; 10 µg BP | $361.00 | |||
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-536148 | 200 µg Ab; 40 µg BP | $361.00 | |||
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 Antibody (E-11): m-IgG1 BP-HRP Bundle | sc-545749 | 200 µg Ab; 20 µg BP | $361.00 | |||
Aldehyde dehydrogenase 4-A1/P5CDH/ALDH4A1 (E-11) Neutralizing Peptide | sc-398776 P | 100 µg/0.5 ml | $69.00 |