9Z,11E,13E-Octadecatrienoic Acid ethyl ester CAS: 42021-86-3
MF: C20H34O2
MW: 306.5
A conjugated polyunsaturated fatty acid.

9Z,11E,13E-Octadecatrienoic Acid ethyl ester (CAS 42021-86-3)

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Nomi alternativi: α-ESA ethyl ester; Ethyl α-eleostearate
Applicazione: 9Z,11E,13E-Octadecatrienoic Acid ethyl ester is a conjugated polyunsaturated fatty acid
Numero CAS: 42021-86-3
Peso molecolare: 306.5
Formula molecolare: C20H34O2
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

A conjugated polyunsaturated fatty acid commonly found in plant seed oil which accounts for about 70% in tung oil and 60% of the total fatty acid composition of bitter gourd seed oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.


Referenze

1 Yasui, Y., Hosokawa, M., Sahara, T., et al. Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARγ in human colon cancer caco-2 cells. Prostaglandins Leukot Essent Fatty Acids 75 113-119 (2005). 2 Tsuzuki, T., Tokuyama, Y., Igarashi, M., et al. Tumor growth suppression by a α-eleostearic acid, linolenic acid isomer with a conjugated triene system, via lipid peroxidation. Carcinogenesis 25(8) 1417-1425 (2004). 3 Mizushina, Y., Tsuzuki, T., Eitsuka, T., et al. Inhibitory action of conjugated C18-fatty acids on DNA polymerases and DNA topoisomerases. Lipids 39(10) 977-983 (2004).

Formulazione :
A solution in ethanol
Stato fisico :
Liquid
Solubilità :
Soluble in DMSO (~30 mg/ml), DMF (~30 mg/ml), and ethanol. Insoluble in water.
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
78° C
IC50 :
Apoptosis was induced via lipid peroxidation: EC5050 = 20 µM
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
Numero MDL :
MFCD12912283
SMILES :
CCCC/C=C/C=C/C=C\\CCCCCCCC(=O)OCC

Download SDS (MSDS)

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