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Molecular structure of 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid, CAS Number: 78028-01-0
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid (CAS 78028-01-0)
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Alternate Names:
CAY10397; CK47A
Application:
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid is a selective inhibitor of 15-hydroxy PGDH
CAS Number:
78028-01-0
Molecular Weight:
328.32
Molecular Formula:
C17H16N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid is a selective inhibitor of 15-hydroxy PGDH (IC50 ~ 10 µM) which acts to prolong the lifetime and activity of endogenously produced prostaglandins in cell cultures. 5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid has also been shown to oxidize the 15-hydroxyl group and hydrogenate the 13,14-double bond on prostaglandins, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity.
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid (CAS 78028-01-0) References
- 15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. | Wei, C., et al. 2009. Mol Pharmacol. 76: 516-25. PMID: 19535459
- Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain. | Glaser, ST. and Kaczocha, M. 2010. J Pharmacol Exp Ther. 335: 380-8. PMID: 20702753
- Increase in intracellular PGE2 induces apoptosis in Bax-expressing colon cancer cell. | Lalier, L., et al. 2011. BMC Cancer. 11: 153. PMID: 21524287
- 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid. | Liu, X., et al. 2011. Chem Res Toxicol. 24: 2227-36. PMID: 21916491
- Crucial role of macrophage selenoproteins in experimental colitis. | Kaushal, N., et al. 2014. J Immunol. 193: 3683-92. PMID: 25187657
- 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. | Wendell, SG., et al. 2015. J Biol Chem. 290: 5868-80. PMID: 25586183
- Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules. | Grabocka, E. and Bar-Sagi, D. 2016. Cell. 167: 1803-1813.e12. PMID: 27984728
- Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. | Theodore, LN., et al. 2017. Stem Cell Reports. 8: 1226-1241. PMID: 28416284
- The Essential Role of Selenoproteins in the Resolution of Citrobacter rodentium-Induced Intestinal Inflammation. | Nettleford, SK., et al. 2020. Front Nutr. 7: 96. PMID: 32775340
- Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues. | Berry, CN., et al. 1983. Biochem Pharmacol. 32: 2863-71. PMID: 6138042
Inhibitor of:
PGDH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid, 1 mg | sc-205129 | 1 mg | $45.00 | |||
5-[[4-(ethoxycarbonyl)phenyl]azo]-2-hydroxy-benzeneacetic acid, 5 mg | sc-205129A | 5 mg | $270.00 |