Neuramidase, from A. ureafaciens Activators
Neuraminidase Activators are a collection of chemical compounds that serve to enhance the catalytic efficiency and substrate specificity of Neuraminidase by modulating its surrounding biochemical milieu. For instance, Zanamivir, while typically an inhibitor, can at sub-inhibitory concentrations induce conformational changes that increase Neuraminidase's activity, possibly by stabilizing the enzyme in an active form or by enhancing substrate affinity. Siastatin B and DANA, although they act as competitive inhibitors, can similarly upregulate Neuraminidase activity at low concentrations that do not fully occlude the active site, instead optimizing substrate-enzyme interactions. Furthermore, Curcumin and Galanthamine, by upregulating related glycoside hydrolases and influencing glycosidase activities, respectively, may enhance the functional activity of Neuraminidase by increasing the pool of available substrates or by stabilizing the enzyme-substrate complex.
Specific activators like Genipin, Hesperidin, and Quercetin alter enzyme activities within the sialic acid metabolic pathways, thereby potentially increasing the availability of Neuraminidase substrates or modifying the enzyme's local environment to favor its activity. Resveratrol's polyphenolic structure enables it to modulate pathways that could lead to a higher turnover of substrates for Neuraminidase. Natural substrates such as Sialyllactose, in addition to serving as Neuraminidase's targets, may also act as allosteric enhancers under certain conditions, optimizing the enzyme's activity. Lastly, compounds like Sodium taurocholate and Deoxycholate, which can disrupt cell membranes, may indirectly increase Neuraminidase activity by enhancing enzyme accessibility to substrates, suggesting that alterations in membrane integrity can serve as a means to regulate the operational efficiency of Neuraminidase.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zanamivir | 139110-80-8 | sc-208495 | 1 mg | $270.00 | 6 | |
Zanamivir is a transition-state analog inhibitor of influenza neuraminidase. It binds to the active site of neuraminidase, leading to its competitive inhibition. However, at sub-inhibitory concentrations, Zanamivir can promote subtle conformational changes in neuraminidase, indirectly enhancing its enzymatic activity. | ||||||
N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid | 24967-27-9 | sc-215433 sc-215433A sc-215433B | 5 mg 10 mg 25 mg | $168.00 $278.00 $549.00 | ||
DANA is a neuraminidase inhibitor that mimics the natural substrate of neuraminidase. At sub-inhibitory doses, DANA can bind neuraminidase in a manner that may increase the binding efficiency of the natural substrate, leading to an indirect enhancement of the enzyme's functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound with anti-inflammatory properties. It can modulate a range of biological processes, including those involved in enzyme activation. Curcumin has been shown to increase the expression of certain glycoside hydrolases, potentially enhancing neuraminidase activity through upregulation in bacterial systems. | ||||||
Galanthamine | 357-70-0 | sc-218556 | 10 mg | $320.00 | ||
Galanthamine is an alkaloid that can inhibit acetylcholinesterase, but it also has been found to influence glycosidase activities. It may indirectly enhance neuraminidase activity by altering glycoside processing pathways, which could increase the availability of substrates for neuraminidase. | ||||||
Genipin | 6902-77-8 | sc-203057 sc-203057A | 25 mg 100 mg | $82.00 $246.00 | 6 | |
Genipin is a natural iridoid compound that can act as a crosslinker for proteins and influence various enzymes. Genipin may modulate the activity of enzymes involved in sialic acid metabolism, leading to indirect effects on neuraminidase activity by affecting substrate availability or enzyme stability. | ||||||
Hesperidin | 520-26-3 | sc-205711 sc-205711A | 25 g 100 g | $82.00 $204.00 | 5 | |
Hesperidin is a flavanone glycoside found in citrus fruits. It has the potential to modulate glycosidase activities, which could influence neuraminidase activity. Hesperidin's effects on related enzymes and its interaction with glycosides suggest it may indirectly enhance neuraminidase activity by affecting the enzyme's environment. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid known for its antioxidant properties. It can modulate various enzyme activities, potentially influencing neuraminidase indirectly. Quercetin's effects on cellular pathways involved in the metabolism of glycoproteins suggest a possible enhancement of neuraminidase activity through substrate interactions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound with diverse biological effects, including enzyme modulation. It could indirectly enhance neuraminidase activity by influencing cellular pathways related to sialic acid metabolism, which may affect neuraminidase substrate availability or activity. | ||||||