L-type Ca++ CP γ4 Activators
The activators of the L-type Calcium Channel, gamma subunit 4 (L-type Ca++ CP γ4), primarily involve a range of calcium channel blockers, each indirectly enhancing the functional activity of the protein through modulation of channel dynamics and interaction with other channel subunits. Nifedipine and Amlodipine, as dihydropyridine calcium channel blockers, influence L-type Ca++ CP γ4 by potentially causing compensatory upregulation or increasing the sensitivity of the gamma subunit. This action is due to their selective binding to the channel's alpha subunit, which plays a crucial role in channel assembly and regulation. Verapamil and Diltiazem, representing phenylalkylamine and benzothiazepine classes, respectively, affect the kinetics of L-type calcium channels. Their influence could enhance L-type Ca++ CP γ4 activity by altering the channel's conformation and thus impacting the regulatory role of the gamma subunit.
Further contributing to the regulation of L-type Ca++ CP γ4, Isradipine, Nicardipine, and Nimodipine, also belonging to the dihydropyridine class, may modulate the channel's pharmacological properties, indirectly enhancing the activity of the gamma subunit. Their binding to the alpha subunit alters the dynamics and function of the channel, emphasizing the gamma subunit's role in channel stability and regulation. Felodipine, Lacidipine, Manidipine, Lercanidipine, and Cilnidipine, each a dihydropyridine derivative, similarly modulate the operation of L-type calcium channels. Their action might influence the L-type Ca++ CP γ4 by affecting channel kinetics and the gamma subunit's contribution to channel function and regulation. These activators, through their varied effects on L-type calcium channels, indirectly but significantly contribute to the enhanced activity of L-type Ca++ CP γ4, crucial for its role in calcium signaling and cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine, a dihydropyridine calcium channel blocker, selectively targets L-type calcium channels. It indirectly enhances L-type Ca++ CP γ4 activity by binding to the alpha subunit, which could lead to a compensatory upregulation or increased sensitivity of the gamma subunit. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine, another dihydropyridine calcium channel blocker, operates similarly to Nifedipine. It could indirectly increase L-type Ca++ CP γ4 activity by modulating the channel's overall function, affecting the gamma subunit's role in channel assembly and regulation. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil, a phenylalkylamine calcium channel blocker, targets L-type calcium channels. It may enhance L-type Ca++ CP γ4 activity indirectly by influencing the channel kinetics and the interaction of the gamma subunit with other channel components. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem, a benzothiazepine calcium channel blocker, selectively influences L-type calcium channels. It could enhance L-type Ca++ CP γ4 activity by altering the channel's conformation, potentially affecting the gamma subunit's regulatory role. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $88.00 $324.00 | 1 | |
Isradipine, a dihydropyridine derivative, selectively inhibits L-type calcium channels. It could indirectly enhance L-type Ca++ CP γ4 activity by modulating the channel dynamics, which involves the gamma subunit's function in channel stability and regulation. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
Nimodipine, a dihydropyridine calcium channel blocker, targets L-type channels. It could indirectly enhance L-type Ca++ CP γ4 activity by affecting the channel's pharmacological properties, which involves the gamma subunit's role in modulating channel activity. | ||||||
Felodipine | 72509-76-3 | sc-201483 sc-201483A | 10 mg 50 mg | $91.00 $222.00 | 1 | |
Felodipine, a dihydropyridine derivative, selectively modulates L-type calcium channels. It might enhance L-type Ca++ CP γ4 activity indirectly by influencing channel kinetics and the gamma subunit's contribution to channel function. | ||||||
trans Lacidipine | 103890-78-4 | sc-213066 | 10 mg | $153.00 | ||
Lacidipine, a dihydropyridine calcium channel blocker, may indirectly enhance L-type Ca++ CP γ4 activity. Its action on the channel could affect the gamma subunit's role in channel assembly and regulation. | ||||||
Manidipine | 89226-50-6 | sc-211774 | 10 mg | $278.00 | ||
Manidipine, a dihydropyridine derivative, targets L-type calcium channels. It could indirectly enhance L-type Ca++ CP γ4 activity by modulating the channel's operation, influencing the gamma subunit's regulatory role. | ||||||
Cilnidipine | 132203-70-4 | sc-201485 sc-201485A sc-201485B | 10 mg 50 mg 1 g | $74.00 $284.00 $450.00 | 1 | |
Cilnidipine, a dihydropyridine derivative, selectively influences L-type calcium channels. It could enhance L-type Ca++ CP γ4 activity by modulating the channel's overall function, potentially affecting the gamma subunit's role. | ||||||