L-type Ca++ CP α1C Activators
L-type calcium channels are an essential class of voltage-gated calcium channels (VGCCs) present predominantly in cardiac and smooth muscle cells, as well as in neurons. These channels play a critical role in regulating calcium influx in response to membrane depolarization, thereby initiating various cellular processes. The "L" in L-type stands for "Long-lasting," pertaining to the sustained current they produce. These channels are composed of multiple subunits, but the main pore-forming subunit is referred to as α1C or Ca_V1.2. This subunit is responsible for the primary functional properties of the channel, such as voltage sensitivity and ion selectivity.
L-type Ca++ CP α1C activators are chemical compounds that specifically enhance the activity of the α1C subunit. By promoting the channel's open state or increasing its sensitivity to depolarization, these activators facilitate the influx of calcium ions through the L-type channels. This increase in calcium influx can lead to the modulation of various intracellular pathways, particularly those related to calcium-dependent processes. It's important to note that the precise mechanism of action of these activators can vary, with some directly interacting with the α1C subunit, while others may modulate associated proteins or signaling pathways to indirectly increase channel activity. Overall, L-type Ca++ CP α1C activators are crucial tools in understanding the intricate role of L-type calcium channels in cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate the expression of several genes. In certain cell types, retinoic acid has been shown to upregulate the expression of L-type calcium channels. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
It's the active form of vitamin D and has been implicated in the regulation of numerous genes, including the potential upregulation of L-type calcium channels in specific tissues. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can lead to the enhanced expression of several proteins, potentially including L-type calcium channels. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can influence the expression of various genes. Some studies have suggested that it might enhance the expression of L-type calcium channels. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a β-adrenergic receptor agonist. Through the β-adrenergic pathway, it can potentially enhance the expression of L-type calcium channels. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
As an estrogen, E2 can bind to estrogen receptors, modulating the expression of various genes. This includes potential upregulation of L-type calcium channels in specific tissues. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
As an aldosterone antagonist, spironolactone can impact the expression of various genes, potentially including the L-type calcium channels in certain cells. | ||||||