HYAL4 Activators
Hyaluronidases are a class of enzymes involved in the breakdown of hyaluronic acid (HA), a major component of the extracellular matrix. Hyaluronidase-4 (HYAL4) is one of the hyaluronidase enzymes, and its activity plays a role in regulating the levels of hyaluronic acid in various tissues. Activators of HYAL4 refer to chemical compounds or molecules that modulate the enzymatic activity of HYAL4. These activators may function by enhancing the catalytic efficiency of HYAL4, influencing its substrate specificity, or regulating its expression.
Understanding the molecular mechanisms and structural characteristics of HYAL4 activators is crucial for elucidating their potential impact on hyaluronic acid metabolism. Researchers may investigate the interactions between these activators and HYAL4 at the molecular level, exploring how these compounds influence the enzyme's function. Such studies contribute to a deeper understanding of the physiological processes involving hyaluronic acid and may have implications for various biological functions. It is important to consult the latest scientific literature for the most up-to-date information on HYAL4 activators and their biochemical roles.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $208.00 | ||
Hyaluronic Acid is a nonsulfated glycosaminoglycan. HYAL4 is a hyaluronidase that degrades hyaluronic acid. Increased concentration of hyaluronic acid can enhance HYAL4 activity as it provides more substrate for the enzyme to act upon. | ||||||
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $35.00 $56.00 $141.00 $431.00 $973.00 | 2 | |
4-Methylumbelliferone is a hyaluronic acid synthesis inhibitor. By inhibiting the synthesis of hyaluronic acid, this compound indirectly increases the activity of HYAL4 by reducing the competition for its substrates. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to affect multiple signaling pathways including the SIRT1 pathway. It can enhance HYAL4 activity by increasing the expression of SIRT1, a protein known to regulate HYAL4. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). As PKC regulates the expression of many proteins, including HYAL4, PMA indirectly enhances HYAL4 activity by activating PKC. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It modulates the expression of many genes, including those involved in the regulation of HYAL4, thus enhancing its activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. It influences multiple biological processes and can enhance HYAL4 activity by affecting cell differentiation and proliferation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase. By causing an increase in intracellular calcium concentration, it can affect many signaling pathways including those involving HYAL4. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short chain fatty acid that affects gene expression by inhibiting histone deacetylase. Sodium butyrate can thus indirectly enhance HYAL4 activity by affecting the epigenetic regulation of its expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D is an antibiotic that binds to the GpC step of DNA, inhibiting the transcription. By affecting the transcription of other hyaluronidases, it can enhance the relative activity of HYAL4. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubules, altering intracellular transport and cell division. This can enhance the activity of HYAL4 by affecting its localization and the cellular environment in which it functions. | ||||||