FAM118A Activators
FAM118A Activators represent a collection of compounds that influence distinct signaling pathways or cellular processes, leading to the activation of FAM118A. Forskolin raises cAMP levels, which activates PKA and results in the phosphorylation of FAM118A, enhancing its role in cellular signaling. Similarly, the Epac Selective cAMP Analog and 8-CPT-cAMP specifically activate Epac proteins, which are responsive to cAMP, leading to the activation of small GTPases like Rap1 and consequent activation of FAM118A, particularly affecting cell adhesion and morphology. Okadaic Acid and Calyculin A exert their effects by inhibiting phosphatases PP1 and PP2A, this, in turn, prevents dephosphorylation and maintains FAM118A in an activated state.
Anisomycin activates stress-activated protein kinases which lead to the enhancement of FAM118A's function in stress response. Phorbol 12-Myristate 13-Acetate (PMA), through the activation of PKC, phosphorylates and activates FAM118A, integrating it into signaling pathways. Dibutyryl-cAMP, another cAMP analog, permeates cells to activate PKA, thereby facilitating the enhancement of FAM118A activity. Ionomycin and Thapsigargin raise intracellular calcium levels, which activate calcium-dependent kinases that phosphorylate and enhance FAM118A, linking it to calcium signaling pathways. Lithium Chloride inhibits GSK-3, leading to the increased phosphorylation and subsequent activation of FAM118A. Bisindolylmaleimide I can under specific conditions lead to the activation of certain PKC isoforms, and thus indirectly result in the activation of FAM118A, revealing the complex regulatory networks that FAM118A is involved in.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-pCPT-2′-O-Me-cAMP | 634207-53-7 | sc-257020 | 1 mg | $306.00 | 5 | |
8-CPT-cAMP is a cAMP analog that selectively activates Epac proteins, leading to downstream effects on the actin cytoskeleton and cell adhesion. This enhances FAM118A's role in cytoskeletal organization. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This indirect inhibition results in the enhanced phosphorylation and activation of FAM118A. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs), leading to the phosphorylation and enhancement of proteins involved in stress response, including FAM118A. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which phosphorylates a broad range of substrates. Through PKC activation, FAM118A is phosphorylated and its function in signaling pathways is enhanced. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of PP1 and PP2A phosphatases. By inhibiting dephosphorylation, it indirectly increases the phosphorylation state of FAM118A, thereby enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog. It activates PKA which then enhances FAM118A activity through phosphorylation, impacting signaling pathways where FAM118A is involved. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent kinases that phosphorylate FAM118A, thus enhancing its activity in calcium signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by blocking the ER Ca2+ ATPase, leading to increased cytosolic calcium and activation of calcium-dependent kinases that can enhance FAM118A function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, a kinase involved in phosphorylation events. Inhibition of GSK-3 leads to an increase in phosphorylation levels of substrates like FAM118A, enhancing its activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a PKC inhibitor that, paradoxically, can lead to the activation of specific PKC isoforms under certain conditions, resulting in the enhanced activation of FAM118A. | ||||||