eotaxin-3 Activators
Eotaxin-3 activators encompass a diverse array of chemical compounds that amplify the functional activity of eotaxin-3 by engaging distinct cellular signaling pathways. For instance, adenosine and Forskolin elevate intracellular cAMP levels, a critical second messenger in signaling pathways that modulate immune cell trafficking. This increase in cAMP can subsequently augment the activity of eotaxin-3, thereby facilitating the directed movement of eosinophils. Similarly, Prostaglandin E2 operates through the EP2 and EP4 receptors to raise cAMP within cells, which in turn can enhance the expression and function of eotaxin-3, promoting eosinophil migration. Histamine, by signaling through the H1 receptor, activates phospholipase C, resulting in a surge in intracellular calcium levels that can further potentiate eotaxin-3's chemotactic role. The inflammatory response is a complex interplay of signals where substances like Lipopolysaccharides activate TLR4, triggering a cascade that activates NF-kB and upregulates eotaxin-3, intensifying its ability to attract eosinophils to sites of inflammation.
Phorbol 12-myristate 13-acetate, known as PMA, stimulates protein kinase C, which has a role in the transcriptional regulation of chemokines like eotaxin-3, enhancing its chemotactic efficacy. Platelet-activating factor and Vitamin D3 also contribute to the activation of signaling mechanisms that culminate in increased expression and activity of eotaxin-3, with PAF activating PLC and increasing intracellular calcium signaling, while Vitamin D3 modulates gene transcription. Environmental and dietary factors such as ozone and retinoic acid, respectively, can induce pathways that lead to the upregulation of eotaxin-3. Ozone exposure activates oxidative stress pathways, while retinoic acid interacts with nuclear receptors, both resulting in enhanced eotaxin-3 activity in immune surveillance and inflammation. Collectively, these chemical activators, through their targeted effects on cellular signaling, facilitate the amplification of eotaxin-3-mediated functions without necessitating its direct activation or increased expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine interacts with adenosine receptors affecting a myriad of signaling pathways including the activation of adenylate cyclase. This can lead to an increase in cAMP which, in turn, enhances the signaling cascade that promotes the activity of eotaxin-3 by affecting leukocyte trafficking. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 interacts with the EP2 and EP4 receptors, leading to increased intracellular cAMP levels. This activation can modulate chemokine expression profiles, including the upregulation and functional activity of eotaxin-3, thereby facilitating eosinophil migration. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine, through the H1 receptor, can stimulate phospholipase C (PLC) activity, resulting in increased intracellular calcium levels and activation of downstream signaling cascades that can enhance the expression and function of eotaxin-3, which is involved in immune cell chemotaxis. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS binds to the TLR4 receptor, initiating a signaling cascade that results in the activation of NF-kB. This transcription factor plays a role in upregulating inflammatory mediators including eotaxin-3, thereby increasing its activity in attracting eosinophils to the site of inflammation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can modulate various cellular functions, including the transcriptional regulation of chemokines like eotaxin-3, thus enhancing its chemotactic activity. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
PAF, through its receptor, can activate PLC and increase intracellular calcium signaling, leading to the activation of various transcription factors involved in the upregulation of eotaxin-3, enhancing its chemotactic function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylate cyclase, increasing cAMP levels, which can lead to the activation of downstream signaling cascades that enhance eotaxin-3 activity, particularly in the context of eosinophilic response. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 (Cholecalciferol) through its receptor can influence the transcription of various genes, including those encoding chemokines. This can lead to an upregulation of eotaxin-3 expression, thereby enhancing its activity in immune cell chemotaxis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid interacts with its nuclear receptors to modulate gene expression. It can influence the expression of eotaxin-3, enhancing the chemokine's activity in immune surveillance and inflammation by promoting eosinophil migration. | ||||||