CHIP Activators
Common CHIP Activators include, but are not limited to 17-AAG CAS 75747-14-7, MG-132 [Z-Leu- Leu-Leu-CHO] CAS 133407-82-6, Celastrol, Celastrus scandens CAS 34157-83-0, Withaferin A CAS 5119-48-2 and Valproic Acid CAS 99-66-1.
CHIP (Carboxyl-terminus of Hsc70 Interacting Protein) activators are compounds or molecules that enhance the activity or function of the CHIP protein. CHIP is a crucial component of the cellular quality control system, which regulates the degradation and clearance of misfolded or damaged proteins. This system is vital for maintaining protein homeostasis within cells, ensuring that only properly folded and functional proteins perform their intended roles. CHIP primarily functions as an E3 ubiquitin ligase, which means it tags target proteins for degradation by the proteasome or lysosome. To perform this role, CHIP interacts with molecular chaperones like Hsp70 and Hsp90, as well as with the co-chaperone Hsp70/90-organizing protein (HOP). Together, these proteins collaborate to recognize, refold, or eliminate misfolded proteins. CHIP activators are of particular interest in cellular biology and protein science because they modulate the activity of the cellular quality control system, influencing the fate of specific proteins within the cell.
Studies focusing on CHIP activators aim to understand how these compounds or molecules interact with CHIP and how they affect its ubiquitin ligase activity. By enhancing CHIP's activity, these activators accelerate the degradation of specific target proteins, thus providing a mechanism to regulate protein levels associated with various cellular processes. Additionally, investigating CHIP activators may have implications in fields such as neurodegenerative diseases and cancer, where misfolded or aggregated proteins play a role in disease pathology. However, it's essential to note that while research in this area is promising, the development of CHIP activators for specific applications is an ongoing area of study and may require further exploration.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
An HSP90 inhibitor that can upregulate CHIP expression as part of the cellular response to misfolded protein accumulation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can influence CHIP expression indirectly by modulating proteostasis. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
An HSP90 inhibitor that can enhance CHIP expression, promoting degradation of misfolded proteins. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Induces heat shock response and might upregulate CHIP expression as part of the cellular adaptive mechanism. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
HDAC inhibitor that may influence CHIP expression by altering chromatin structure. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Has been shown to modulate CHIP activity, potentially influencing its expression and subsequent ubiquitination processes. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
A vacuolar-type H+-ATPase inhibitor that might influence CHIP expression indirectly through its effects on cellular proteostasis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
ER stress inducer that might upregulate CHIP expression as part of the unfolded protein response (UPR). | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Another ER stress inducer that can influence CHIP expression as part of the UPR. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Green tea polyphenol that can influence CHIP expression and activity, potentially promoting degradation of specific substrates. | ||||||