CANT1 Activators
Calcium chloride increases the calcium concentration, can directly enhance the enzyme's activity. This is complemented by the action of certain compounds that disrupt the calcium storage mechanisms; Thapsigargin and Cyclopiazonic Acid undermine the calcium-sequestering role of SERCA pumps, leading to a surge in the cytosolic calcium that can stimulate CANT1 activity. Simultaneously, ionophores like Ionomycin and A23187 facilitate calcium's entry into the cell, providing an immediate boost to its availability and thereby fostering an environment conducive to CANT1 activation. Elsewhere in the cell, Ryanodine and Dantrolene act on specific calcium release channels, which can result in a cascade effect, indirectly promoting the conditions for CANT1 activation.
Further complexity is added by agents such as 2-APB and SKF-96365, which, while primarily targeting calcium entry pathways, ultimately contribute to the overall cellular calcium dynamics influencing CANT1. Additionally, interventions with calcium channel blockers, such as Nifedipine and Verapamil, can perturb calcium influx, indirectly affecting CANT1 by triggering cellular adaptive responses aimed at maintaining calcium equilibrium. While these chemicals do not directly interact with CANT1, their impact on calcium homeostasis creates a cascade of events that can lead to the activation of the enzyme.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Increases intracellular calcium levels, which can activate CANT1 as it is a calcium-activated nucleotidase. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to an increase in cytosolic calcium concentration, which can indirectly activate CANT1. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Acts as a calcium ionophore, elevating intracellular calcium levels, which can activate CANT1. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
A cell-permeable calcium chelator that, upon intracellular hydrolysis, can lead to transient increases in intracellular calcium that could activate CANT1. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Functions similarly to Ionomycin as a calcium ionophore, raising intracellular calcium levels and potentially activating CANT1. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Inhibits SERCA, causing an increase in cytosolic calcium levels, which may result in the activation of CANT1. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Modulates the ryanodine receptor and can indirectly increase intracellular calcium concentration, which can activate CANT1. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Modulates store-operated calcium entry and can lead to changes in intracellular calcium levels, potentially activating CANT1. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
Inhibits receptor-mediated calcium entry channels, which could lead to compensatory calcium signaling mechanisms activating CANT1. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Blocks voltage-dependent L-type calcium channels, potentially causing a compensatory increase in intracellular calcium that could activate CANT1. | ||||||