C9orf43 Activators
EGCG and curcumin, for example, are known to affect multiple signal transduction pathways, which can lead to changes in the phosphorylation state of proteins, a post-translational modification that often regulates protein function. Resveratrol, by activating SIRT1, alters the acetylation status of proteins, thereby influencing their activity and stability. Sulforaphane and spermidine, through activation of Nrf2 and induction of autophagy, respectively, can bring about changes in protein expression and degradation, thereby modifying protein activity.
Quercetin and genistein, with their capacity to inhibit kinase activity, can affect protein function by altering phosphorylation cascades. Capsaicin's effect on TRPV1 receptors and the subsequent signaling pathways may also modulate protein activities. Compounds like 1,1-Dimethylbiguanide, Hydrochloride and rapamycin, which activate AMPK and inhibit mTOR respectively, have broad effects on cellular metabolism and growth. These changes can cascade down to affect the activity of a wide range of proteins, potentially including those similar to C9orf43. Pioglitazone, as a PPAR-gamma agonist, affects gene transcription, which can alter protein function. Lithium's inhibition of GSK-3β may impact Wnt signaling, affecting protein stability and function within this pathway.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Known to modulate signal transduction pathways, potentially influencing proteins by altering phosphorylation states. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Anti-inflammatory properties; modulates various signaling pathways, including NF-κB, which could indirectly modify protein activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenolic compound that activates SIRT1, leading to deacetylation of target proteins, potentially affecting their function and stability. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Activates Nrf2, a transcription factor that can alter the expression of detoxification enzymes and may influence protein activity through redox regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that has been shown to inhibit kinase activity, thereby potentially altering phosphorylation cascades that regulate protein activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone that acts as a tyrosine kinase inhibitor, potentially affecting signaling pathways and protein activities that depend on phosphorylation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
An active component of chili peppers that can influence TRPV1 receptors and might affect downstream signaling pathways and protein activities. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
A polyamine that is known to induce autophagy, a process that could modify the turnover and function of various proteins. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Activates AMPK, a master regulator of metabolism, and may indirectly influence protein activity by altering cellular energy status. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
A PPAR-gamma agonist that can change the transcription of genes involved in metabolism, potentially affecting protein function. | ||||||