ATBF1 Activators
ATBF1 Activators encompass a range of chemical compounds that indirectly augment the functional activity of ATBF1, particularly in transcriptional regulation, neuronal differentiation, and tumorigenesis. Forskolin, by elevating cAMP levels and thereby activating PKA, can modulate transcription factors and co-regulators that interact with ATBF1, thereby impacting gene expression. This modulation is essential in ATBF1's involvement in neuronal differentiation and its role in tumor suppression. Similarly, Dibutyryl-cAMP, a cAMP analog, enhances PKA activity, potentially influencing ATBF1 function in transcriptional regulation in both neuronal and cancer cells. Histone deacetylase inhibitors like Trichostatin A and Sodium Butyrate modify chromatin structure and gene expression, crucial for ATBF1's regulatory functions. Retinoic Acid, by modulating gene expression involved in differentiation, indirectly enhances ATBF1's activity in neuronal pathways.
In addition to these, Epigallocatechin gallate, a kinase inhibitor, and LY294002, a PI3K inhibitor, indirectly activate ATBF1 by modulating signaling pathways that affect transcriptional co-regulators of ATBF1 in both neuronal and oncogenic contexts. The DNA methyltransferase inhibitor, 5-Azacytidine, potentially augments ATBF1 function by altering DNA methylation patterns, impacting gene expression crucial for ATBF1's role in transcriptional regulation. Compounds like Curcumin and Resveratrol modulate various signaling pathways and cellular stress responses, influencing ATBF1's function in cancer cell regulation and tumor suppression. Moreover, 17-AAG, an HSP90 inhibitor, affects protein folding and stability, thereby influencing ATBF1's role in transcriptional regulation. Lastly, SB431542, by inhibiting TGF-β receptor signaling, can modulate pathways intersecting with ATBF1's role in cellular differentiation and cancer progression. Collectively, these ATBF1 Activators, through their targeted effects on transcriptional regulation, signaling pathways, and chromatin remodeling, enhance the pivotal role of ATBF1 in neuronal development and cancer cell regulation, underscoring its significance in these vital biological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates cAMP levels, leading to PKA activation, which can indirectly enhance ATBF1 activity. Increased PKA activity can modulate transcription factors and co-regulators interacting with ATBF1, impacting gene expression related to neuronal differentiation and tumorigenesis. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, raises intracellular cAMP levels, enhancing PKA activity. This activation may indirectly influence ATBF1 function by affecting transcriptional regulation in neuronal cells and cancer cells. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, another histone deacetylase inhibitor, may indirectly enhance ATBF1 function by modifying gene expression patterns, particularly influencing ATBF1-mediated transcriptional regulation in cancer cells. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid can indirectly enhance ATBF1 activity by modulating gene expression involved in neuronal differentiation, a process in which ATBF1 plays a significant role. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate, a kinase inhibitor, may indirectly activate ATBF1 by modulating signaling pathways that affect transcription factors and co-regulators associated with ATBF1 in neuronal and cancer cells. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, may indirectly enhance ATBF1 function by altering DNA methylation patterns, affecting gene expression crucial for ATBF1's role in transcriptional regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can indirectly enhance ATBF1 activity by modulating various signaling pathways and transcription factors, impacting ATBF1's function in neuronal differentiation and cancer cell regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, through its antioxidative properties, may indirectly enhance ATBF1 function by modulating cellular stress responses, which can influence ATBF1's role in transcriptional regulation and tumor suppression. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG, an HSP90 inhibitor, can indirectly enhance ATBF1 activity by affecting protein folding and stability, influencing ATBF1’s role in transcriptional regulation and cancer cell growth. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, may indirectly enhance ATBF1 function by modulating TGF-β signaling pathways, which intersect with ATBF1's role in cellular differentiation and tumorigenesis. | ||||||