A230051G13Rik Activators
Chemical activators of the IBA57 homolog can initiate various biochemical pathways to enhance its role in mitochondrial iron-sulfur cluster assembly. Sulfasalazine activates the antioxidant response element (ARE) pathway, inducing the nuclear translocation of Nrf2, which may bolster mitochondrial function and, in turn, the activity of the IBA57 homolog. Sodium selenite, through its role as a cofactor for antioxidant enzymes such as glutathione peroxidases, helps to mitigate oxidative stress in mitochondria, thus preserving the integrity of iron-sulfur clusters and supporting the function of the IBA57 homolog. Methylene blue acts as an artificial electron donor within the mitochondrial electron transport chain, facilitating the assembly of iron-sulfur clusters by providing a favorable redox environment that aids the IBA57 homolog's activity.
Furthermore, Coenzyme Q10, integral to the electron transport chain, enhances mitochondrial performance, creating an optimal environment for the IBA57 homolog's function in iron-sulfur cluster assembly. Alpha-lipoic acid, as a cofactor for mitochondrial enzymes, reduces oxidative damage and improves mitochondrial function, indirectly supporting the IBA57 homolog. N-acetylcysteine, a precursor to glutathione, lowers oxidative stress and helps maintain the integrity of iron-sulfur clusters, thereby aiding the IBA57 homolog. Nicotinamide, essential for NAD+ synthesis, sustains mitochondrial health and the electron transport chain, augmenting the IBA57 homolog's activity. Riboflavin is crucial for FAD synthesis, a cofactor in mitochondrial respiration, which indirectly promotes the IBA57 homolog's function. Copper sulfate enhances cytochrome c oxidase function, thus supporting mitochondrial respiration and the IBA57 homolog. Ferrous sulfate provides iron for iron-sulfur cluster formation, directly aiding the IBA57 homolog. Zinc sulfate, through its antioxidant properties, indirectly supports the IBA57 homolog by maintaining mitochondrial integrity. Lastly, Manganese(II) sulfate supplies manganese, which is essential for mitochondrial enzymes that detoxify superoxide radicals, thus facilitating the function of the IBA57 homolog.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine can activate the antioxidant response element (ARE) pathway by inducing the nuclear translocation of the transcription factor Nrf2. The IBA57 homolog is involved in the mitochondrial iron-sulfur cluster assembly; Nrf2 activation may enhance the mitochondrial function and indirectly increase the activity of mitochondrial proteins, including IBA57 homolog. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Sodium selenite acts as a cofactor for antioxidant enzymes like glutathione peroxidases. These enzymes play a role in mitigating oxidative stress in mitochondria. Mitigating oxidative stress can preserve the integrity of iron-sulfur clusters, potentially supporting the function of IBA57 homolog in iron-sulfur cluster assembly within mitochondria. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Methylene blue can serve as an artificial electron donor in the mitochondrial electron transport chain. By donating electrons, it may enhance the assembly of iron-sulfur clusters by maintaining a favorable redox environment, thus functionally activating the IBA57 homolog involved in cluster assembly. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 functions within the mitochondrial electron transport chain and can improve mitochondrial performance. Enhanced electron transport chain function can indirectly activate IBA57 homolog by creating an optimal environment for iron-sulfur cluster assembly. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is an essential cofactor for mitochondrial enzymes and can also act as an antioxidant. By improving mitochondrial function and reducing oxidative damage, it may indirectly activate the IBA57 homolog by promoting the assembly of iron-sulfur clusters. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-acetylcysteine serves as a precursor to glutathione, a major cellular antioxidant. Increased glutathione can reduce oxidative stress, which may help maintain the integrity of iron-sulfur clusters. This reduction in oxidative stress can thus support the activity of the IBA57 homolog in cluster assembly. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 and a precursor to NAD+, which is essential for mitochondrial function and the electron transport chain. Adequate NAD+ levels can support mitochondrial health, indirectly promoting the activity of IBA57 homolog in the assembly of iron-sulfur clusters. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin is vital for the synthesis of flavin adenine dinucleotide (FAD), a cofactor in mitochondrial respiration. By supporting mitochondrial electron transport, riboflavin can indirectly activate IBA57 homolog by promoting a favorable environment for iron-sulfur cluster formation. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper sulfate can provide copper ions, which are cofactors for cytochrome c oxidase in the electron transport chain. The improved function of cytochrome c oxidase can enhance mitochondrial respiration, supporting an environment that promotes the activation of the IBA57 homolog for iron-sulfur cluster assembly. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate provides zinc ions that can act as an antioxidant and protect mitochondrial integrity. By preserving mitochondrial function, zinc ions can indirectly support the activation of IBA57 homolog, facilitating its role in iron-sulfur cluster assembly. | ||||||