8-oxoG DNA Lesion Activators
8-oxoG DNA Lesion Activators are a diverse class of chemical compounds that enhance the activity of the DNA repair enzymes responsible for the recognition and repair of 8-oxoG lesions through the base excision repair pathway. Metal ions such as Zinc, Manganese, and Magnesium play a crucial role as cofactors, enhancing the structural stability and catalytic efficiency of key enzymes in the repair process. These ions ensure the proper function of DNA glycosylases, polymerases, and ligases, which are necessary for the excision of damaged bases, synthesis of new DNA strands, and sealing of DNA nicks, respectively.
Energy-providing molecules such as NAD+ and ATP are indispensable for the enzymatic activities within the BER pathway. NAD+ specifically enhances the function of PARP1, which aids in recruiting the repair machinery to damaged DNA sites, while ATP is vital for the DNA ligation step. Biotin, SAM, and TPP are metabolic cofactors that support the cellular environment required for optimal DNA repair. Flavonoids and Selenium compounds exert protective antioxidant effects that maintain the integrity of DNA repair enzymes. Moreover, supplements like Uridine and Alpha-lipoic acid provide the necessary substrates for DNA repair synthesis and protect the repair enzymes from oxidative stress, respectively, ensuring the continuous and efficient repair of 8-oxoG DNA lesions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can act as a cofactor for DNA glycosylases such as OGG1, which recognize and remove 8-oxoG lesions, thereby enhancing the initial recognition and excision step of the BER pathway. | ||||||
Manganese | 7439-96-5 | sc-250292 | 100 g | $270.00 | ||
Manganese ions can similarly act as cofactors for enzymes involved in the BER pathway, enhancing their catalytic activity for the repair of 8-oxoG lesions. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
Nicotinamide adenine dinucleotide (NAD+) improves the activity of PARP1, a protein that can recruit BER machinery to sites of DNA damage, including 8-oxoG lesions. | ||||||
Adenosine 5′-Triphosphate, disodium salt | 987-65-5 | sc-202040 sc-202040A | 1 g 5 g | $39.00 $75.00 | 9 | |
Adenosine triphosphate (ATP) is essential for the DNA ligation step of BER, providing the energy required for ligase enzymes to seal nicks after 8-oxoG removal. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
Biotin can enhance the activity of biotin-dependent carboxylases, which may indirectly affect DNA repair pathways by modulating cellular metabolism and cofactor availability. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM serves as a methyl donor in numerous methylation reactions, which can influence gene expression and potentially enhance the expression of enzymes involved in BER. | ||||||
Thiamine pyrophosphate | 154-87-0 | sc-215966 sc-215966A sc-215966B sc-215966C sc-215966D | 1 g 5 g 25 g 100 g 1 kg | $33.00 $97.00 $290.00 $1149.00 $6024.00 | 1 | |
TPP is a cofactor for the enzyme transketolase, which can affect the pentose phosphate pathway and nucleotide synthesis, thereby supporting the BER process. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoids can modulate cellular antioxidant status, potentially reducing oxidative stress and the burden of oxidative DNA lesions like 8-oxoG. | ||||||
Uridine | 58-96-8 | sc-296685 sc-296685A | 1 g 25 g | $61.00 $100.00 | 1 | |
Uridine supplementation can enhance the nucleotide pool, which is crucial for DNA repair synthesis steps in the BER pathway. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid acts as an antioxidant, which can protect DNA repair enzymes from oxidative damage, thus maintaining their activity for 8-oxoG repair. | ||||||