4930428D18Rik Activators
Chemical activators of claudin 34B4 include a variety of compounds that influence cellular pathways and junctional complexes. Benzalkonium chloride is known to enhance the integrity of tight junctions, which are crucial in epithelial cell barriers. The activation of claudin 34B4 by this chemical can be attributed to its ability to affect junctional complexes, leading to improved tight junction integrity. Similarly, forskolin, through its action of increasing intracellular cAMP levels, activates adenylate cyclase, which subsequently leads to the activation of protein kinase A (PKA). PKA can phosphorylate claudin 34B4, thereby promoting its role in tight junction assembly and regulation. Dibutyryl-cAMP also activates PKA, which can have a direct effect on the phosphorylation state of claudin 34B4, enhancing its function in tight junctions.
Moreover, Zinc Pyrithione's role in increasing intracellular zinc levels can contribute to the stabilization of tight junction structures and consequently the activation of claudin 34B4. Retinoic acid, by influencing cell differentiation and junction formation, supports the activation of claudin 34B4 in maintaining tight junctions. Genistein, as a tyrosine kinase inhibitor, can enhance tight junction assembly by indirectly activating claudin 34B4. The ROCK inhibitors Y-27632 and Thiazovivin reduce actomyosin tension, which allows for the correct localization and functioning of tight junction proteins, including claudin 34B4. Calcium chloride is pivotal for the formation and maintenance of tight junctions, thereby activating claudin 34B4's role in this process. Lastly, H-89, by modulating PKA activity, and SP600125, as a JNK inhibitor, can influence the phosphorylation states and activation of claudin 34B4 within tight junctions. Tannic acid also supports the assembly and function of tight junctions, hence promoting the activation of claudin 34B4. These chemicals, through their varied modes of action, all contribute to the activation of claudin 34B4, underscoring its integral role in the maintenance of tight junction integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, directly activates PKA. Through PKA activation, this compound might lead to the phosphorylation and subsequent activation of claudin 34B4, thereby enhancing its role in tight junction formation and function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc pyrithione can increase intracellular levels of zinc, which is known to stabilize the structure of tight junctions. Zinc-induced stabilization of tight junctions can promote the functional activation of claudin 34B4, as it is a constituent protein of these junctions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences cell differentiation and junction formation. Through its role in cell junction development, it can lead to the activation of claudin 34B4 as part of the process of forming and maintaining tight junctions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, indirectly activates tight junction proteins by inhibiting occludin and claudin phosphorylation, which can lead to enhanced tight junction assembly. This activity can include the activation of claudin 34B4 in the process of strengthening the tight junctions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that can enhance tight junction formation by reducing actomyosin tension. Reduced tension allows for the correct localization and function of tight junction proteins, including claudin 34B4, thus leading to its activation in the context of tight junction assembly and maintenance. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions play a critical role in the formation and maintenance of tight junctions. As claudin 34B4 is a tight junction protein, the presence of calcium chloride can activate the function of claudin 34B4 in promoting tight junction integrity. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
Thiazovivin is a ROCK inhibitor, similar to Y-27632, which can promote tight junction integrity by modulating cytoskeletal dynamics. This allows for the activation of claudin 34B4 as it participates in tight junction assembly and strengthening. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Tannic acid has been shown to enhance the barrier function of epithelial layers. It can activate claudin 34B4 by promoting the assembly and function of tight junctions, where claudin 34B4 plays a pivotal role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, which can have an impact on tight junction assembly. By modulating JNK activity, SP600125 can activate claudin 34B4 function in the context of its role in the formation and regulation of tight junctions within epithelial cells. | ||||||